PGS and endorsement of the 11 individual diagnostic criteria for DSM-5 TUD and 4 of the 6 FTND criteria (excluding CPD and smoking when ill) in NESARC-III (N = 12,482; DSM-TUD N cases = 4,205). Linear regression models were used to estimate associations between PGSs and the total DSM-5 TUD criterion count and total FTND criterion count. All regression models covaried for age, sex, and 10 within-ancestry principal components. We first ran a model with only the DSM-NicDep PGS as a predictor, then a model with only the FTND PGS as a predictor, and finally a model where all four PGSs (DSM-NicDep, FTND, ICD-TUD, and CPD) were included jointly as predictors.
