We also created PGSs for DSM-NicDep, FTND, and CPD in the BioVU biobank (we did not create a PGS for ICD-TUD, because BioVU was included in that published GWAS meta-analysis). We used the methods described above to create the PGS and tested whether the DSM-NicDep, FTND, and CPD PGS were associated with ICD-TUD (N = 66,914; N cases = 9,666) in BioVU in a logistic regression model that controlled for age, sex, and 10 ancestry principal components.
