Chunk #102 — Quantification and Statistical Analysis — Level 4 - Differential Expression (ZSPC)

Source

A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.

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where X is the vector of normalized gene expression of gene x across all samples on the plate, MAD is the median absolute deviation of X, and the factor of 1.4826 makes the denominator a consistent estimator of scale for normally distributed data.