Chunk #101 — Quantification and Statistical Analysis — Level 4 - Differential Expression (ZSPC)

Source

A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.

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To obtain a measure of relative gene expression, we use a robust z-scoring procedure to generate differential expression values from normalized profiles. We compute the differential expression of gene x in the ith sample on the plate as