The pattern of results was similar across all SNPs. We present in Figure 2 results for rs279858 since it has been one of the most widely studied and replicated SNPs in GABRA2 (Covault, Gelernter et al. 2004; Edenberg, Dick et al. 2004; Lappalainen, Krupitsky et al. 2005; Lind, Macgregor et al. 2008; Bierut, Agrawal et al. 2010). Figure 2 shows the estimated growth trajectories for each of the different genotypes. As illustrated in the figure, the trajectory of the A-A genotype (the major allele homozygote) is characterized by a significantly greater jump in drunkenness between 18 to 19 years of age. None of the slope differences for rs279858 were significant after correction for multiple testing.
