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Chunk #15 — Results

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Genetic influences on alcohol use across stages of development: GABRA2 and longitudinal trajectories of drunkenness from adolescence to young adulthood.
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Posthoc analyses were run to test for potential sex effects by fitting the models to the data for females and males separately (Tables 2 and 3). Although similar trends are observed for both females and males, the effect of genotype on the jump in drunkenness observed between adolescence and adulthood was significant only in females. Only those females who were homozygous for the major allele showed a large jump in drunkenness from 18 to 19 years (Figure 3A). Males who were homozygous for the major allele also showed the highest levels of drunkenness (Table 3; Figure 3B), but it was only significant with one SNP. Males overall showed higher levels of drunkenness, contributing to the lack of significant differences by genotype.