We began by using bivariate LD Score regression10 to quantify the amount of genetic overlap between each of our three phenotypes and ten neuropsychiatric and physical health phenotypes. Figures 2b and c display the estimates for subjective well-being and the negative of the estimates for depressive symptoms and neuroticism (since subjective well-being is negatively genetically correlated with depressive symptoms and neuroticism). Subjective well-being, depressive symptoms, and neuroticism have strikingly similar patterns of pairwise genetic correlation with the other phenotypes.
