Figure 2b shows the results for the five neuropsychiatric phenotypes we examined: Alzheimer’s disease, anxiety disorders, autism spectrum disorder, bipolar disorder, and schizophrenia. For four of these phenotypes, genetic correlations with depression (but not neuroticism or subjective well-being) were reported in Bulik-Sullivan et al.10. For schizophrenia and bipolar disorder, our estimated correlations with depressive symptoms, 0.33 and 0.26, are substantially lower than Bulik-Sullivan et al.’s point estimates but contained within their 95% confidence intervals. By far the largest genetic correlations we estimate are with anxiety disorders: −0.73 with subjective well-being, 0.88 with depressive symptoms, and 0.86 with neuroticism. Genetic correlations estimated from GWAS data have not been previously reported for anxiety disorders.
