We also examined genome-wide, region-specific associations in each disorder separately, combining deletions and duplications. In OCD, 16p13.11 again emerged as the locus with the most notable patient:control excess (6:1; one-sided empirical p=0.046, genome-wide permutation-corrected p=0.35). In TS, the 3p26.3 region had the largest patient:control excess (7:2 ratio of duplications 50kb upstream of CNTN6; 1-sided empirical p=0.018, genome-wide permutation-corrected p=0.15); exonic CNTN6 regions had a more equivocal patient-control ratio (8:6; 1-sided empirical p=0.11, genome-wide permutation-corrected p=0.99; see Figure S7, available online).
