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Chunk #7 — Method — Statistical framework

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Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group.
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We performed both a meta-analysis (i.e., using group statistics from the independent studies) and mega-analysis (i.e., pooling extracted measures from individual subjects across sites, while adjusting for site effects) to be consistent with our prior paper. In this manuscript we will focus on the mega-analysis. See Supplementary Information SI3 for methods, results and discussion of the meta-analysis.