Structural T1-weighted MRI brain scans were acquired and processed locally. Image acquisition parameters for each site are given in Supplementary Table S3. All cortical parcellations were performed with the fully automated segmentation software FreeSurfer, version 5.3 (20), following standardized ENIGMA protocols to harmonize analyses and quality control procedures across multiple sites (see http://enigma.usc.edu/protocols/imaging-protocols/). Segmentation of 68 (34 left and 34 right) cortical gray matter regions based on the Desikan-Killiany atlas (21) and two whole-hemisphere measures were visually inspected and statistically evaluated for outliers. Details on image exclusion criteria and quality control are presented in Supplementary Information SI1.
