paperKB
coga / coga-kb
Help
Sign in

Chunk #32 — RESULTS — Genotype-specific expression

Source
Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample.
Embedded
yes

Text

The SMRI postmortem CON samples were genotyped for rs1344706. Allele frequencies in the N=30 CON samples were A: 32/60, 0.533; C: 28/60, 0.477, and were in good agreement with data from the HapMap (A: 0.567; C: 0.433) and Irish (A: 0.607; C: 0.393) samples. Expression is significantly higher for the associated A allele (t=2.129, df=39, p=0.033, Figure 1B). The observed difference was not due to effects of potential confounder variables assessed by ANOVA (age, post-mortem interval, refrigeration interval, brain pH or smoking, F=0.829; df=12; p=0.62).