Inspection of the sequence around SNP rs1344706 shows that it lies in a short region of conserved mammalian sequence in intron 2 of ZNF804A. MatInspector results for the 53 bp of sequence we assessed (chr2:185,486,646-185,486,698) include the A allele of rs1344706 in the predicted binding sites for two brain-expressed transcription factors, Myt1L53,54 and POU3F1/Oct-655, both implicated in multiple CNS developmental processes, particularly in oligodendrocytes54,55. Two additional binding sites are predicted in the presence of the C allele. One of these is for the ubiquitously expressed Homez56 and the other is for Hmx2, which, while expressed in the CNS, is thought to be primarily involved in the development of the inner ear57–59 (Figure S2).
