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Chunk #20 — Results — Microarray analysis — Within-groups analysis: BP iPSC vs BP neurons and control iPSC vs control neurons

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Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients.
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Both sets of iPSC express similar pluripotency factors, positive regulators of cell cycle, genes involved in very early embryonic development, signaling molecules, and factors involved in proliferation. They express few anterior-posterior patterning factors (HOX) and numerous genes involved in chromatin modification. There were slight variations in the expression of individual transcripts between groups, but the functional significance, if any, of these differences is not known.