Chunk #19 — Results — Microarray analysis — Within-groups analysis: BP iPSC vs BP neurons and control iPSC vs control neurons

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Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients.

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i. Transcripts enriched in iPSC Functional Annotation Chart Analysis identified 475 Gene Ontology (GO) terms associated with genes expressed at significantly higher levels in BP iPSC than in differentiated BP neurons; 463 terms in control iPSC vs neurons. These included transcripts involved in cell cycle control, RNA binding and genes involved in development (Table 1 summarizes clusters involved in early differentiation).