Chunk #18 — Results — Microarray analysis — Within-groups analysis: BP iPSC vs BP neurons and control iPSC vs control neurons

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Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients.

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Transcripts expressed in iPSC and neurons There were 14 993 unique transcripts that were significantly differentially expressed in BP iPSC compared with neurons derived from them; there were 15 311 transcripts in control iPSC vs control neurons that were significantly altered. Of these, 7242 transcripts were expressed at twofold or higher levels in BP iPSC, 5120 were expressed at ⩾ twofold levels in BP-derived neurons. In control cells, 7098 unique transcripts were expressed at twofold or higher levels in iPSC and 5089 at ⩾ twofold levels in neurons.