Chunk #8 — Materials and methods — Genotyping and imputation

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Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain.

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Markov Chain based haplotyper (MACH 1.0.16) was used to impute non-assayed genotypes for blood and brain datasets independently using the June 2010 release of the 1000 Genomes Project build-36 reference panel, using default settings for MACH. Imputed SNPs were excluded from the analysis if their minor allele frequency (MAF) was < 0.01 and if their r2 was < 0.3.