We calculated power for three sets of models: (1) testing pleiotropy between nicotine dependence and each of the comorbid disorders, (2) testing pleiotropy while adjusting for nicotine dependence, and (3) testing genetic risk moderation for nicotine dependence by each of the comorbid disorders. To compute the power for detecting the various interaction effect sizes, we focus on the power for the interaction of AA_CC diplotype for rs16969968 and rs588765 with comorbid disorders.
