Despite these promising findings, the individual loci did not replicate in any of the replication samples (Supplemental Table S6; lowest p =0.06 for chr5:141988181 in Yale-Penn) and meta-analysis across COGA and the replication samples did not retain their genome-wide significance, although findings for the chromosome 3 locus were in the same direction in the AA samples, and for chromosome 1 in the EA samples. In the UK Biobank, there was weak evidence of association between alcohol intake frequency and rs1890881 (beta=−0.010, p=0.026). In addition, rs1890881 was marginally associated with cannabis use (beta=0.029, p=0.048) in the current largest GWAS of the trait27. There was evidence of association between alcohol intake and rs74611272 (beta=0.016, p=0.007;26), the strongest signal in the EA GWAS, in the UK Biobank.
