As shown in Table 5, carriers of the minor (C) allele of rs75168521 (chr 13), which was associated with increased likelihood of ANYDEP in COGA, had blunted right (beta=−0.111, p=0.004), but not left (beta=−0.065, p=0.143), VS activation in the AA subsample. However, rs34066662 genotype (chr 3) was not associated with VS activity in either hemisphere among AAs, despite a similar directional pattern (betas>−0.075, ps >0.103). As expected, among EA there was no association between rs75168521 or rs34066662 genotype and VS activation in either hemisphere (|betas|<0.025, ps >0.247). Carriers of the minor (C) allele of rs1890881 (chr 1), which was associated with decreased likelihood of ANYDEP in the trans-ancestral meta-analysis (effect driven by alcohol dependence), were characterized by blunted reactivity of the left VS among AA (beta=−0.134, p=0.001). Nominally significant associations that were not robust to Bonferroni correction were observed between rs1890881 genotype and right VS activation in AA (beta = −0.098, p = 0.013) and left (beta=−0.036, p=0.029), but not right (beta=−0.004, p=0.801), VS activation among EA.
