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Chunk #2 — Introduction

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Medial orbitofrontal cortex gray matter is reduced in abstinent substance-dependent individuals.
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yes

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The data used for this study were collected as part of a study in which we reported reduced prefrontal brain activity in SDI compared to controls during decision making (15). The task was a modified Iowa Gambling Task (IGT) which simulates uncertainty and reward of real-life decision making initially developed to test impaired decision making in patients with ventral medial prefrontal cortex lesions (16). We extend those results here by determining if the volume of medial OFC gray matter is lower in abstinent SDI compared to controls