Medial orbitofrontal cortex gray matter is reduced in abstinent substance-dependent individuals.
paper
Cited
Public
- Authors
- Tanabe, Jody; Tregellas, Jason R; Dalwani, Manish; Thompson, Laetitia; Owens, Elizabeth; Crowley, Thomas; Banich, Marie
- Year
- 2009
- Journal
- Biological psychiatry
- PMID
- 18801475
- DOI
- 10.1016/j.biopsych.2008.07.030
- PMCID
- PMC2640220
BACKGROUND: Chronic exposure to drugs of addiction induces cellular adaptations in orbitofrontal cortex (OFC) and associated limbic-prefrontal pathways that might underlie abuse-related behavior. A propensity to make risky decisions in spite of substantial negative consequences might be mediated by medial OFC dysfunction in substance-dependent individuals (SDI). We tested the hypothesis that medial OFC gray matter (GM) volume would be lower in SDI compared with control subjects. METHODS: Nineteen SDI and 20 control subjects participated. The SDI were dependent on two or more substances, most often cocaine, amphetamine, and alcohol, with mean duration of abstinence 4.7, 2.4, and 3.2 years, respectively. High-resolution T1-weighted images were acquired on a 3-T magnetic resonance system. Image processing and analyses were conducted with voxel-based morphometry (VBM) implemented in Statistical Parametric Mapping (SPM) 5. Differences in regional GM volume were tested with an analysis of covariance model, co-varying for global GM and age. Statistical maps were set at p < .05, corrected for multiple comparisons. Medial OFC GM volume was correlated with behavioral performance on a modified gambling task. RESULTS: There was lower GM volume specifically in bilateral medial OFC in SDI compared with control subjects. There was a small but significant correlation between medial OFC GM and persistence of playing high-risk decks on a modified gambling task. CONCLUSIONS: This is the first study to use VBM with whole brain correction for multiple comparisons in SDI after prolonged abstinence. Reduced medial OFC GM might reflect long-term adaptations within the reward-learning circuit underlying pathological decision-making in substance dependence.
No figures extracted from this document.
1–20 of 28
Next →
| Name | Type |
|---|---|
| 1.5T MRI local | drug |
| 3D T1-weighted SPGR-IR sequence local | drug |
| 3T MRI local | drug |
| abstinence | phenotype |
| abstinent substance dependent individuals local | cohort |
| abuse and dependence symptom count local | phenotype |
| addiction | phenotype |
| age | phenotype |
| alcohol | phenotype |
| amphetamine | drug |
| anterior cingulate cortex | anatomy |
| anterior temporal lobes local | anatomy |
| ARTS local | cohort |
| avoidance of bad cards local | phenotype |
| avoidance of bad decks local | phenotype |
| bad decks local | phenotype |
| bilateral medial orbital frontal cortex local | anatomy |
| bipolar disorder | phenotype |
| brain structure | anatomy |
| brain volume | anatomy |
| chronic cocaine users local | cohort |
| cocaine | phenotype |
| cocaine-treated rats local | cohort |
| control | cohort |
| controls | cohort |
| Cortico-striatal-limbic circuit local | anatomy |
| date of last use local | phenotype |
| Decision making behavior local | phenotype |
| decision-making deficits | phenotype |
| deficits in reversal learning local | phenotype |
| Dopamine transporter availability local | phenotype |
| drug dependence | phenotype |
| education | phenotype |
| encephalomalacia local | phenotype |
| EPI T2* images local | drug |
| frontal cortex | anatomy |
| Frontal_Med_Orb_Left local | anatomy |
| Frontal_Med_Orb_Right local | anatomy |
| global GM local | phenotype |
| GM volume local | anatomy |
| GM volume local | phenotype |
| gray matter | anatomy |
| gray matter-white matter contrast-to-noise ratio (CNR) local | phenotype |
| group | cohort |
| HIV infection | phenotype |
| illicit drugs | phenotype |
| impaired decision making local | phenotype |
| impaired outcome evaluation local | phenotype |
| insula | anatomy |
| International Consortium for Brain Mapping local | cohort |
| IQ | phenotype |
| left medial orbitofrontal cortex | anatomy |
| lentiform nucleus | anatomy |
| limbic system | anatomy |
| major depressive disorder | phenotype |
| marijuana | phenotype |
| Matlab 7.5 local | drug |
| medial OFCGM local | anatomy |
| medial OFC GM volume local | phenotype |
| medial OFC gray matter volume local | anatomy |
| medial orbital frontal cortex (OFC) local | anatomy |
| medial orbitofrontal cortex | anatomy |
| metabolic abnormalities local | phenotype |
| Methadone | drug |
| methamphetamine | drug |
| methamphetamine dependence | phenotype |
| middle frontal lobe local | anatomy |
| motion artifact local | phenotype |
| multiple substances | drug |
| nucleus accumbens | anatomy |
| opiate addiction local | phenotype |
| opiates | drug |
| opioid dependence | phenotype |
| orbitofrontal cortex | anatomy |
| other drugs | drug |
| parietal cortex | anatomy |
| pathological decision making behavior local | phenotype |
| performance | phenotype |
| poly-substance abusers local | cohort |
| poor decision making | phenotype |
| precentral gyrus | anatomy |
| prefrontal brain activity local | phenotype |
| prefrontal cortex | anatomy |
| protracted abstinence | phenotype |
| relapse | phenotype |
| right medial orbitofrontal cortex | anatomy |
| SDI local | cohort |
| SDI cohort (current study) local | cohort |
| severity of drug dependence local | phenotype |
| sex | phenotype |
| SPM5 local | drug |
| striatum | anatomy |
| substance dependent individuals local | cohort |
| substance dependent individual (SDI) local | phenotype |
| substance use | phenotype |
| superior frontal lobe local | anatomy |
| symptom count | phenotype |
| temporal cortex | anatomy |
| thalamus | anatomy |
| total GM local | anatomy |
| total GM local | phenotype |
| Total gray matter local | anatomy |
| ventral medial frontal cortex local | anatomy |
| ventral medial OFC local | anatomy |
| ventral medial orbital frontal cortex local | anatomy |
| ventral medial prefrontal cortex lesions local | anatomy |
| Voxel-based morphometry toolbox (VBM5.1) local | drug |
| Wechsler Abbreviated Scale of Intelligence | drug |
| white matter | anatomy |
| whole brain | anatomy |
No uploaded files.
Not in any collection.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Persistent appetitive memory in problematic pornography users. | Kampa M et al. | — | 2026 | → |
| Modification of inhibitory control and craving through transcranial direct current stimulation as an add-on treatment for substance use disorder: protocol for a randomized controlled study. | Vollstädt-Klein S et al. | — | 2025 | → |
| Frontal white and gray matter abnormality in gambling disorder: A multimodal MRI study. | Bellmunt-Gil A et al. | — | 2024 | → |
| Common and distinct fronto-striatal volumetric changes in heroin and cocaine use disorders. | Ceceli AO et al. | — | 2023 | → |
| Effects of current smoking severity on brain gray matter volume in opioid use disorder - a voxel-based morphometry study. | Shi Z et al. | — | 2023 | → |
| Functional and structural brain abnormalities in substance use disorder: A multimodal meta-analysis of neuroimaging studies. | Yan H et al. | — | 2023 | → |
| Medial orbitofrontal cortical regulation of different aspects of Pavlovian and instrumental reward seeking. | Jenni NL et al. | — | 2023 | → |
| Neurocognitive Impulsivity in Opiate Users at Different Lengths of Abstinence. | Psederska E et al. | — | 2023 | → |
| Neuropsychiatric and Neuropsychological Aspects of Alcohol-Related Cognitive Disorders: An In-Depth Review of Wernicke's Encephalopathy and Korsakoff's Syndrome. | Eva L et al. | — | 2023 | → |
| The Effects of Cognitive Impulsivity on the Duration of Remission in Alcohol-Dependent Patients. | Galkin SA | — | 2023 | → |
| The Role of Non-coding RNAs in Methamphetamine-Induced Neurotoxicity. | Xu L et al. | — | 2023 | → |
| To bridge or not to bridge: Moral Judgement in Cocaine Use Disorders, a case-control study on human morality. | Mosca A et al. | — | 2023 | → |
| Amygdala-cortical collaboration in reward learning and decision making. | Wassum KM | — | 2022 | → |
| Impaired verbal memory in individuals living with HIV and cocaine dependence. | Nigro SE et al. | — | 2022 | → |
| Morphometric similarity deviations in stimulant use disorder point towards abnormal brain ageing. | Zhukovsky P et al. | — | 2022 | → |
| Prefrontal cortical activation in Internet Gaming Disorder Scale high scorers during actual real-time internet gaming: A preliminary study using fNIRS. | Cho TH et al. | — | 2022 | → |
| The neurobiology of drug addiction: cross-species insights into the dysfunction and recovery of the prefrontal cortex. | Ceceli AO et al. | — | 2022 | → |
| Medial orbitofrontal cortex dopamine D<sub>1</sub>/D<sub>2</sub> receptors differentially modulate distinct forms of probabilistic decision-making. | Jenni NL et al. | — | 2021 | → |
| Memory impairment in alcohol use disorder is associated with regional frontal brain volumes. | Fama R et al. | — | 2021 | → |
| Methamphetamine abuse disturbs the dopaminergic system to impair hippocampal-based learning and memory: An overview of animal and human investigations. | Shukla M et al. | — | 2021 | → |
| Orbitofrontal cortex and dorsal striatum functional connectivity predicts incubation of opioid craving after voluntary abstinence. | Fredriksson I et al. | — | 2021 | → |
| Orbitofrontal cortex thickness and substance use disorders in emerging adulthood: causal inferences from a co-twin control/discordant twin study. | Harper J et al. | — | 2021 | → |
| Promising vulnerability markers of substance use and misuse: A review of human neurobehavioral studies. | Lees B et al. | — | 2021 | → |
| The medial orbitofrontal cortex - basolateral amygdala circuit regulates the influence of reward cues on adaptive behavior and choice | Lichtenberg NT et al. | — | 2021 | — |
| The Medial Orbitofrontal Cortex-Basolateral Amygdala Circuit Regulates the Influence of Reward Cues on Adaptive Behavior and Choice. | Lichtenberg NT et al. | — | 2021 | → |
| TRAIL Mediates Neuronal Death in AUD: A Link between Neuroinflammation and Neurodegeneration. | Qin L et al. | — | 2021 | → |
| Unlocking the reinforcement-learning circuits of the orbitofrontal cortex. | Groman SM et al. | — | 2021 | → |
| Benefits of EEG-Neurofeedback on the Modulation of Impulsivity in a Sample of Cocaine and Heroin Long-Term Abstinent Inmates: A Pilot Study. | Corominas-Roso M et al. | — | 2020 | → |
| Deficient Decision Making in Pathological Gamblers Correlates With Gray Matter Volume in Medial Orbitofrontal Cortex. | Freinhofer D et al. | — | 2020 | → |
| Diurnal Preference and Grey Matter Volume in a Large Population of Older Adults: Data from the UK Biobank. | Norbury R | — | 2020 | → |
| Mechanisms of Shared Vulnerability to Post-traumatic Stress Disorder and Substance Use Disorders. | María-Ríos CE et al. | — | 2020 | → |
| Reduced fractional anisotropy in projection, association, and commissural fiber networks in neonates with prenatal methamphetamine exposure. | Warton FL et al. | — | 2020 | → |
| Selective impact of lateral orbitofrontal cortex inactivation on reinstatement of alcohol seeking in male Long-Evans rats. | Arinze I et al. | — | 2020 | → |
| The associations of comorbid substance use disorders and psychiatric conditions with adolescent brain structure and function: A review. | Kroll DS et al. | — | 2020 | → |
| White Matter Abnormalities Based on TBSS and Its Correlation With Impulsivity Behavior of Methamphetamine Addicts. | Huang S et al. | — | 2020 | → |
| A comparison of implicit and explicit reward learning in low risk alcohol users versus people who binge drink and people with alcohol dependence. | Paelecke-Habermann Y et al. | — | 2019 | → |
| A Pilot Study of Neurocognitive Function and Brain Structures in Adolescents With Alcohol Use Disorders: Does Maltreatment History Matter? | De Bellis MD et al. | — | 2019 | → |
| Brain-behavior relations and effects of aging and common comorbidities in alcohol use disorder: A review. | Sullivan EV et al. | — | 2019 | → |
| Longitudinal changes in cocaine intake and cognition are linked to cortical thickness adaptations in cocaine users. | Hirsiger S et al. | — | 2019 | → |
| Neural mechanisms of extinguishing drug and pleasant cue associations in human addiction: role of the VMPFC. | Konova AB et al. | — | 2019 | → |
| Neurobiological substrates of persistent working memory deficits and cocaine-seeking in the prelimbic cortex of rats with a history of extended access to cocaine self-administration. | Gobin C et al. | — | 2019 | → |
| Neuroimaging of reward mechanisms in Gambling disorder: an integrative review. | Clark L et al. | — | 2019 | → |
| Neuroimaging reward, craving, learning, and cognitive control in substance use disorders: review and implications for treatment. | Tanabe J et al. | — | 2019 | → |
| Reward. | Wallis JD | — | 2019 | → |
| Sexual trauma history is associated with reduced orbitofrontal network strength in substance-dependent women. | Poppa T et al. | — | 2019 | → |
| The role of neurocognitive functioning, substance use variables and the DSM-5 severity scale in cocaine relapse: A prospective study. | Lima DR et al. | — | 2019 | → |
| Volumetric Prefrontal Cortex Alterations in Patients With Alcohol Dependence and the Involvement of Self-Control. | Rosenthal A et al. | — | 2019 | → |
| Decoding diagnosis and lifetime consumption in alcohol dependence from grey-matter pattern information. | Guggenmos M et al. | — | 2018 | → |
| Developmental Trajectories of the Orbitofrontal Cortex and Anhedonia in Middle Childhood and Risk for Substance Use in Adolescence in a Longitudinal Sample of Depressed and Healthy Preschoolers. | Luby JL et al. | — | 2018 | → |
| Gray and white matter integrity influence TMS signal propagation: a multimodal evaluation in cocaine-dependent individuals. | Kearney-Ramos TE et al. | — | 2018 | → |
| Prenatal methamphetamine exposure is associated with corticostriatal white matter changes in neonates. | Warton FL et al. | — | 2018 | → |
| Presumed structural and functional neural recovery after long-term abstinence from cocaine in male military veterans. | He Q et al. | — | 2018 | → |
| The role of the orbitofrontal cortex in alcohol use, abuse, and dependence. | Moorman DE | — | 2018 | → |
| Adolescent Corticosterone and TrkB Pharmaco-Manipulations Sex-Dependently Impact Instrumental Reversal Learning Later in Life. | Barfield ET et al. | — | 2017 | → |
| Altered Gray-Matter Volumes Associated With Betel Quid Dependence. | Yuan F et al. | — | 2017 | → |
| Brain Volume Correlates with Duration of Abstinence from Substance Abuse in a Region-Specific and Substance-Specific Manner. | Korponay C et al. | — | 2017 | → |
| Compulsive sexual behavior: Prefrontal and limbic volume and interactions. | Schmidt C et al. | — | 2017 | → |
| Decreased subcortical volumes in alcohol dependent individuals: effect of polysubstance use disorder. | Grodin EN et al. | — | 2017 | → |
| Effect of tobacco smoking on frontal cortical thickness development: A longitudinal study in a mixed cohort of ADHD-affected and -unaffected youth. | Akkermans SEA et al. | — | 2017 | → |
| Frontal cortex gray matter volume alterations in pathological gambling occur independently from substance use disorder. | Zois E et al. | — | 2017 | → |
| Impulsive-antisocial dimension of psychopathy linked to enlargement and abnormal functional connectivity of the striatum. | Korponay C et al. | — | 2017 | → |
| Impulsive-antisocial psychopathic traits linked to increased volume and functional connectivity within prefrontal cortex. | Korponay C et al. | — | 2017 | → |
| Larger corpus callosum and reduced orbitofrontal cortex homotopic connectivity in codeine cough syrup-dependent male adolescents and young adults. | Qiu YW et al. | — | 2017 | → |
| Overlapping Risky Decision-Making and Olfactory Processing Ability in HIV-Infected Individuals. | Jackson C et al. | — | 2017 | → |
| Prefrontal gray matter volume recovery in treatment-seeking cocaine-addicted individuals: a longitudinal study. | Parvaz MA et al. | — | 2017 | → |
| Structural Neuroimaging in Polysubstance Users. | Meyerhoff DJ | — | 2017 | → |
| The neurobiology of addiction: the perspective from magnetic resonance imaging present and future. | Suckling J et al. | — | 2017 | → |
| Abnormal gray matter volume and resting-state functional connectivity in former heroin-dependent individuals abstinent for multiple years. | Wang L et al. | — | 2016 | → |
| Abnormal prefrontal cortex resting state functional connectivity and severity of internet gaming disorder. | Jin C et al. | — | 2016 | → |
| Alterations of prefrontal cortical microRNAs in methamphetamine self-administering rats: From controlled drug intake to escalated drug intake. | Du HY et al. | — | 2016 | → |
| Amygdala, Hippocampus, and Ventral Medial Prefrontal Cortex Volumes Differ in Maltreated Youth with and without Chronic Posttraumatic Stress Disorder. | Morey RA et al. | — | 2016 | → |
| Brain responses to emotional salience and reward in alcohol use disorder. | Alba-Ferrara L et al. | — | 2016 | → |
| Chronic Drinking During Adolescence Predisposes the Adult Rat for Continued Heavy Drinking: Neurotrophin and Behavioral Adaptation after Long-Term, Continuous Ethanol Exposure. | Fernandez GM et al. | — | 2016 | → |
| From mother to child: orbitofrontal cortex gyrification and changes of drinking behaviour during adolescence. | Kühn S et al. | — | 2016 | → |
| Metacognitive impairment in active cocaine use disorder is associated with individual differences in brain structure. | Moeller SJ et al. | — | 2016 | → |
| Multifaceted impairments in impulsivity and brain structural abnormalities in opioid dependence and abstinence. | Tolomeo S et al. | — | 2016 | → |
| Peripapillary retinal nerve fiber layer thickness in bipolar disorder. | Mehraban A et al. | — | 2016 | → |
| Response inhibition and addiction medicine: from use to abstinence. | Spechler PA et al. | — | 2016 | → |
| Short-term UROD treatment on cerebral function in codeine-containing cough syrups dependent male individuals. | Qiu YW et al. | — | 2016 | → |
| Volumetric brain abnormalities in polysubstance use disorder patients. | Noyan CO et al. | — | 2016 | → |
| White matter disruptions in male cocaine polysubstance users: Associations with severity of drug use and duration of abstinence. | van Son D et al. | — | 2016 | → |
| Alcohol use disorder with and without stimulant use: brain morphometry and its associations with cigarette smoking, cognition, and inhibitory control. | Pennington DL et al. | — | 2015 | → |
| An Update of the Review of Neuropsychological Consequences of HIV and Substance Abuse: A Literature Review and Implications for Treatment and Future Research. | Norman LR et al. | — | 2015 | → |
| Brain perfusion in polysubstance users: relationship to substance and tobacco use, cognition, and self-regulation. | Murray DE et al. | — | 2015 | → |
| Disorders of compulsivity: a common bias towards learning habits. | Voon V et al. | — | 2015 | → |
| Female adolescents with severe substance and conduct problems have substantially less brain gray matter volume. | Dalwani MS et al. | — | 2015 | → |
| Gray matter abnormalities in cocaine versus methamphetamine-dependent patients: a neuroimaging meta-analysis. | Hall MG et al. | — | 2015 | → |
| Higher sensitivity to the conditioned rewarding effects of cocaine and MDMA in High-Novelty-Seekers mice exposed to a cocaine binge during adolescence. | Mateos-García A et al. | — | 2015 | → |
| Risk-taking in disorders of natural and drug rewards: neural correlates and effects of probability, valence, and magnitude. | Voon V et al. | — | 2015 | → |
| Sex Differences in Gray Matter Changes and Brain-Behavior Relationships in Patients with Stimulant Dependence. | Regner MF et al. | — | 2015 | → |
| Smaller amygdala and medial prefrontal cortex predict escalating stimulant use. | Becker B et al. | — | 2015 | → |
| The somatic marker theory in the context of addiction: contributions to understanding development and maintenance. | Olsen VV et al. | — | 2015 | → |
| Volumetric alterations in the nucleus accumbens and caudate nucleus in bulimia nervosa: a structural magnetic resonance imaging study. | Coutinho J et al. | — | 2015 | → |
| Abnormal cortical thickness in heroin-dependent individuals. | Li M et al. | — | 2014 | → |
| A commonly carried genetic variant in the delta opioid receptor gene, OPRD1, is associated with smaller regional brain volumes: replication in elderly and young populations. | Roussotte FF et al. | — | 2014 | → |
| Cerebral gray matter volumes and low-frequency fluctuation of BOLD signals in cocaine dependence: duration of use and gender difference. | Ide JS et al. | — | 2014 | → |
| Functional alteration in frontolimbic systems relevant to moral judgment in cocaine-dependent subjects. | Verdejo-Garcia A et al. | — | 2014 | → |
| Functional, structural, and emotional correlates of impaired insight in cocaine addiction. | Moeller SJ et al. | — | 2014 | → |
| Gray matter volume in left rostral middle frontal and left cerebellar cortices predicts frontal executive performance in alcoholic subjects. | Nakamura-Palacios EM et al. | — | 2014 | → |
| Hemispheric side of damage influences sex-related differences in smoking cessation in neurological patients. | Gaznick N et al. | — | 2014 | → |
| Mechanisms of reward circuit dysfunction in psychiatric illness: prefrontal-striatal interactions. | Pujara M et al. | — | 2014 | → |
| Paralimbic gray matter reductions in incarcerated adolescent females with psychopathic traits. | Cope LM et al. | — | 2014 | → |
| Performance on a strategy set shifting task in rats following adult or adolescent cocaine exposure. | Kantak KM et al. | — | 2014 | → |
| Prelimbic and infralimbic cortical regions differentially encode cocaine-associated stimuli and cocaine-seeking before and following abstinence. | West EA et al. | — | 2014 | → |
| Reduced frontal brain volume in non-treatment-seeking cocaine-dependent individuals: exploring the role of impulsivity, depression, and smoking. | Crunelle CL et al. | — | 2014 | → |
| Reduced ventral medial prefrontal cortex (vmPFC) volume and impaired vmPFC-default mode network integration in codeine-containing cough syrups users. | Qiu YW et al. | — | 2014 | → |
| Resting state functional connectivity of the nucleus accumbens in youth with a family history of alcoholism. | Cservenka A et al. | — | 2014 | → |
| Reward, interrupted: Inhibitory control and its relevance to addictions. | Jentsch JD et al. | — | 2014 | → |
| Structural brain differences in alcohol-dependent individuals with and without comorbid substance dependence. | Mon A et al. | — | 2014 | → |
| Aberrant paralimbic gray matter in incarcerated male adolescents with psychopathic traits. | Ermer E et al. | — | 2013 | → |
| Affective decision-making is predictive of three-month relapse in polysubstance-dependent alcoholics. | De Wilde B et al. | — | 2013 | → |
| Antagonizing 5-HT₂A receptors with M100907 and stimulating 5-HT₂C receptors with Ro60-0175 blocks cocaine-induced locomotion and zif268 mRNA expression in Sprague-Dawley rats. | Burton CL et al. | — | 2013 | → |
| A preliminary investigation of Stroop-related intrinsic connectivity in cocaine dependence: associations with treatment outcomes. | Mitchell MR et al. | — | 2013 | → |
| Are there volumetric brain differences associated with the use of cocaine and amphetamine-type stimulants? | Mackey S et al. | — | 2013 | → |
| A selective insular perfusion deficit contributes to compromised salience network connectivity in recovering alcoholic men. | Sullivan EV et al. | — | 2013 | → |
| Characterizing the cognitive effects of cocaine: a comprehensive review. | Spronk DB et al. | — | 2013 | → |
| Cognitive control dysfunction and abnormal frontal cortex activation in stimulant drug users and their biological siblings. | Smith DG et al. | — | 2013 | → |
| Decision-making deficits are still present in heroin abusers after short- to long-term abstinence. | Li X et al. | — | 2013 | → |
| Decrease of gray matter volume in the midbrain is associated with treatment response in medication-overuse headache: possible influence of orbitofrontal cortex. | Riederer F et al. | — | 2013 | → |
| Deficits in cortical, diencephalic and midbrain gray matter in alcoholism measured by VBM: Effects of co-morbid substance abuse. | Grodin EN et al. | — | 2013 | → |
| Ethanol reduces neuronal excitability of lateral orbitofrontal cortex neurons via a glycine receptor dependent mechanism. | Badanich KA et al. | — | 2013 | → |
| Functional neuroimaging of migraine. | Denuelle M et al. | — | 2013 | → |
| Insula and orbitofrontal cortical morphology in substance dependence is modulated by sex. | Tanabe J et al. | — | 2013 | → |
| Meta-analysis of structural brain abnormalities associated with stimulant drug dependence and neuroimaging of addiction vulnerability and resilience. | Ersche KD et al. | — | 2013 | → |
| Proteomic profile of differentially expressed proteins in the medial prefrontal cortex after repeated cocaine exposure. | Guan X et al. | — | 2013 | → |
| Recovering from cocaine: insights from clinical and preclinical investigations. | Hanlon CA et al. | — | 2013 | → |
| Reduced striatal brain volumes in non-medicated adult ADHD patients with comorbid cocaine dependence. | van Wingen GA et al. | — | 2013 | → |
| Systematic review, structural analysis, and new theoretical perspectives on the role of serotonin and associated genes in the etiology of psychopathy and sociopathy. | Yildirim BO et al. | — | 2013 | → |
| The neurocircuitry of illicit psychostimulant addiction: acute and chronic effects in humans. | Taylor SB et al. | — | 2013 | → |
| Aberrant paralimbic gray matter in criminal psychopathy. | Ermer E et al. | — | 2012 | → |
| A voxel-based morphometry study comparing problem gamblers, alcohol abusers, and healthy controls. | van Holst RJ et al. | — | 2012 | → |
| Cognitive control and the dopamine D₂-like receptor: a dimensional understanding of addiction. | Groman SM et al. | — | 2012 | → |
| Cortical thinning in amphetamine-type stimulant users. | Koester P et al. | — | 2012 | → |
| Decision making, impulsivity, and personality traits in alcohol-dependent subjects. | Tomassini A et al. | — | 2012 | → |
| Enhanced anxiety observed in cocaine withdrawn rats is associated with altered reactivity of the dorsomedial prefrontal cortex. | El Hage C et al. | — | 2012 | → |
| Examining the effect of psychopathic traits on gray matter volume in a community substance abuse sample. | Cope LM et al. | — | 2012 | → |
| Moral decision-making in polysubstance dependent individuals. | Carmona-Perera M et al. | — | 2012 | → |
| Nucleus Accumbens Volume Is Associated with Frequency of Alcohol Use among Juvenile Justice-Involved Adolescents. | Thayer RE et al. | — | 2012 | → |
| Reduced grey matter in the posterior insula as a structural vulnerability or diathesis to addiction. | Gardini S et al. | — | 2012 | → |
| Self-regulation and treatment retention in cocaine dependent individuals: a longitudinal study. | Verdejo-García A et al. | — | 2012 | → |
| Striatal volume increases in active methamphetamine-dependent individuals and correlation with cognitive performance. | Jan RK et al. | — | 2012 | → |
| Structural and behavioral correlates of abnormal encoding of money value in the sensorimotor striatum in cocaine addiction. | Konova AB et al. | — | 2012 | → |
| Structural integrity of the prefrontal cortex modulates electrocortical sensitivity to reward. | Parvaz MA et al. | — | 2012 | → |
| Structural magnetic resonance imaging in eating disorders: a systematic review of voxel-based morphometry studies. | Van den Eynde F et al. | — | 2012 | → |
| The detrimental effects of emotional process dysregulation on decision-making in substance dependence. | Murphy A et al. | — | 2012 | → |
| The involvement of the orbitofrontal cortex in psychiatric disorders: an update of neuroimaging findings. | Jackowski AP et al. | — | 2012 | → |
| Trait impulsivity and prefrontal gray matter reductions in cocaine dependent individuals. | Moreno-López L et al. | — | 2012 | → |
| Voxelwise evaluation of white matter volumes in first-episode psychosis. | Colombo RR et al. | — | 2012 | → |
| Assessing white matter integrity as a function of abstinence duration in former cocaine-dependent individuals. | Bell RP et al. | — | 2011 | → |
| Association between prior alcohol use disorders and decreased prefrontal gray matter volumes in bipolar I disorder patients. | Nery FG et al. | — | 2011 | → |
| Association of frontal and posterior cortical gray matter volume with time to alcohol relapse: a prospective study. | Rando K et al. | — | 2011 | → |
| Diagnosing adult attention deficit/hyperactivity disorder in patients with cocaine dependence: discriminant validity of Barkley executive dysfunction symptoms. | Vergara-Moragues E et al. | — | 2011 | → |
| Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. | Goldstein RZ et al. | — | 2011 | → |
| Dysregulation of limbic and auditory networks in tinnitus. | Leaver AM et al. | — | 2011 | → |
| Effects of chronic intermittent ethanol exposure on orbitofrontal and medial prefrontal cortex-dependent behaviors in mice. | Badanich KA et al. | — | 2011 | → |
| Elevated gray and white matter densities in cocaine abstainers compared to current users. | Hanlon CA et al. | — | 2011 | → |
| Gene x disease interaction on orbitofrontal gray matter in cocaine addiction. | Alia-Klein N et al. | — | 2011 | → |
| Interaction effect of functional variants of the BDNF and DRD2/ANKK1 gene is associated with alexithymia in healthy human subjects. | Walter NT et al. | — | 2011 | → |
| Lower activation in the right frontoparietal network during a counting Stroop task in a cocaine-dependent group. | Barrós-Loscertales A et al. | — | 2011 | → |
| Medial prefrontal gray matter volume reductions in users of amphetamine-type stimulants revealed by combined tract-based spatial statistics and voxel-based morphometry. | Daumann J et al. | — | 2011 | → |
| New findings on biological factors predicting addiction relapse vulnerability. | Sinha R | — | 2011 | → |
| On the use and misuse of genomic and neuroimaging science in forensic psychiatry: current roles and future directions. | Treadway MT et al. | — | 2011 | → |
| Prenatal tactile stimulation attenuates drug-induced behavioral sensitization, modifies behavior, and alters brain architecture. | Muhammad A et al. | — | 2011 | → |
| Reduced amygdala and hippocampal volumes in patients with methamphetamine psychosis. | Orikabe L et al. | — | 2011 | → |
| Reduced cortical gray matter volume in male adolescents with substance and conduct problems. | Dalwani M et al. | — | 2011 | → |
| Reduced dorsal prefrontal gray matter after chronic ketamine use. | Liao Y et al. | — | 2011 | → |
| Reduced striatal volume in cocaine-dependent patients. | Barrós-Loscertales A et al. | — | 2011 | → |
| Regional homogeneity changes in heroin-dependent individuals: resting-state functional MR imaging study. | Qiu YW et al. | — | 2011 | → |
| Right parietal hypoactivation in a cocaine-dependent group during a verbal working memory task. | Bustamante JC et al. | — | 2011 | → |
| Smaller regional gray matter volume in homeless african american cocaine-dependent men: a preliminary report. | Weller RE et al. | — | 2011 | → |
| Altered neural response of the appetitive emotional system in cocaine addiction: an fMRI Study. | Asensio S et al. | — | 2010 | → |
| An epistasis effect of functional variants on the BDNF and DRD2 genes modulates gray matter volume of the anterior cingulate cortex in healthy humans. | Montag C et al. | — | 2010 | → |
| Dysfunctional reward processing in male alcoholics: an ERP study during a gambling task. | Kamarajan C et al. | — | 2010 | → |
| Effect of cocaine on structural changes in brain: MRI volumetry using tensor-based morphometry. | Narayana PA et al. | — | 2010 | → |
| Preference conditioning in healthy individuals: correlates with hazardous drinking. | Balodis IM et al. | — | 2010 | → |
| Reduced thickness of medial orbitofrontal cortex in smokers. | Kühn S et al. | — | 2010 | → |
| Regional grey matter volume abnormalities in bulimia nervosa and binge-eating disorder. | Schäfer A et al. | — | 2010 | → |
| Relationship between impulsivity and decision making in cocaine dependence. | Kjome KL et al. | — | 2010 | → |
| Shared brain vulnerabilities open the way for nonsubstance addictions: carving addiction at a new joint? | Frascella J et al. | — | 2010 | → |
| Advanced neuroimaging of migraine. | Schwedt TJ et al. | — | 2009 | → |
| Evidence for ongoing brain injury in human immunodeficiency virus-positive patients treated with antiretroviral therapy. | Cardenas VA et al. | — | 2009 | → |
| Frontal and cingulate gray matter volume reduction in heroin dependence: optimized voxel-based morphometry. | Liu H et al. | — | 2009 | → |