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Chunk #17 — Results — Correlation between decision making performance and medial OFC gray matter volume

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Medial orbitofrontal cortex gray matter is reduced in abstinent substance-dependent individuals.
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A small, significant negative correlation between medial OFC GM volume and avoidance of bad decks was observed across groups (r=-.39, p=.01,1-tail). After adjusting for age, education, and IQ, the correlation remained significant (r=-.35, p=.03, 1-tail). The correlation was higher in controls (r=-.37) than SDI (r=-.22) but due to small numbers was not significant within group (Figure 3).