Structural brain differences in alcohol-dependent individuals with and without comorbid substance dependence.
- Authors
- Mon, Anderson; Durazzo, Timothy C; Abe, Christoph; Gazdzinski, Stefan; Pennington, David; Schmidt, Thomas; Meyerhoff, Dieter J
- Year
- 2014
- Journal
- Drug and alcohol dependence
- PMID
- 25263262
- DOI
- 10.1016/j.drugalcdep.2014.09.010
- PMCID
- PMC4280666
BACKGROUND: Over 50% of individuals with alcohol use disorders (AUD) also use other substances; brain structural abnormalities observed in alcohol dependent individuals may not be entirely related to alcohol consumption. This MRI study assessed differences in brain regional tissue volumes between short-term abstinent alcohol dependent individuals without (ALC) and with current substance use dependence (polysubstance users, PSU). METHODS: Nineteen, one-month-abstinent PSU and 40 ALC as well as 27 light-drinkers (LD) were studied on a 1.5 T MR system. Whole brain T1-weighted images were segmented automatically into regional gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) volumes. MANOVA assessed group differences of intracranial volume-normalized tissue volumes of the frontal, parietal, occipital, and temporal lobes and regional subcortical GM volumes. The volumetric measures were correlated with neurocognitive measures to assess their functional relevance. RESULTS: Despite similar lifetime drinking and smoking histories, PSU had significantly larger normalized WM volumes than ALC in all lobes. PSU also had larger frontal and parietal WM volumes than LD, but smaller temporal GM volumes and smaller lenticular and thalamic nuclei than LD. ALC had smaller frontal, parietal, and temporal GM, thalamic GM and cerebellar volumes than LD. ALC had more sulcal CSF volumes than both PSU and LD. CONCLUSION: One-month-abstinent ALC and PSU exhibited different patterns of gross brain structural abnormalities. The larger lobar WM volumes in PSU in the absence of widespread GM volume loss contrast with widespread GM atrophy in ALC. These structural differences may demand different treatment approaches to mitigate specific functionally relevant brain abnormalities.
No figures extracted from this document.
No entities extracted from this document yet.
No uploaded files.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry. | 2017 | 28070124 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Cognitive dysfunction and parent-directed aggression. | Curtis A et al. | — | 2026 | → |
| Gray matter volume and its molecular profiles characteristic drinking severity in young adults. | Li G et al. | — | 2026 | → |
| The effects of alcohol use severity and polygenic risk on gray matter volumes in young adults | Chen Y et al. | — | 2025 | — |
| The effects of alcohol use severity and polygenic risk on gray matter volumes in young adults. | Chen Y et al. | — | 2025 | → |
| Neuroanatomical correlates of aggressiveness: a case-control voxel- and surface-based morphometric study. | Seidenbecher S et al. | — | 2024 | → |
| Medication overuse headache and substance use disorder: A comparison based on basic research and neuroimaging. | Li C et al. | — | 2023 | → |
| Pain Catastrophizing Is Associated With Increased Alcohol Cue-Elicited Neural Activity Among Individuals With Alcohol Use Disorder. | Nieto SJ et al. | — | 2022 | → |
| Effects of Prenatal Methamphetamine Exposure on the Developing Human Brain: A Systematic Review of Neuroimaging Studies. | Sanjari Moghaddam H et al. | — | 2021 | → |
| Evaluating effects of sex and age on white matter microstructural alterations in alcohol use disorder: A diffusion tensor imaging study. | Kisner MA et al. | — | 2021 | → |
| Memory impairment in alcohol use disorder is associated with regional frontal brain volumes. | Fama R et al. | — | 2021 | → |
| Substance-Specific and Shared Gray Matter Signatures in Alcohol, Opioid, and Polysubstance Use Disorder. | Muller AM et al. | — | 2021 | → |
| Hippocampal Volume in Psychiatric Diagnoses: Should Psychiatry Biomarker Research Account for Comorbidities? | Gosnell SN et al. | — | 2020 | → |
| Striatal and white matter volumes in chronic ketamine users with or without recent regular stimulant use. | Liang H et al. | — | 2020 | → |
| A Systematic Literature Review of Neuroimaging of Psychopathic Traits. | Johanson M et al. | — | 2019 | → |
| Neurophysiological Correlates and Differential Drug Response in Subjects With a Family History of an Alcohol Use Disorder. | Comstock SM et al. | — | 2019 | → |
| Role of Patient Sex in Early Recovery from Alcohol-Related Cognitive Impairment: Women Penalized. | Luquiens A et al. | — | 2019 | → |
| The Clock Is Ticking - Brain Atrophy in Case of Acute Trauma? | Nikova AS et al. | — | 2019 | → |
| The thalamus in drug addiction: from rodents to humans. | Huang AS et al. | — | 2018 | → |
| An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry. | Meyers JL et al. | — | 2017 | → |
| Decreased subcortical volumes in alcohol dependent individuals: effect of polysubstance use disorder. | Grodin EN et al. | — | 2017 | → |
| Effects of naltrexone are influenced by childhood adversity during negative emotional processing in addiction recovery. | Savulich G et al. | — | 2017 | → |
| Immune activation and neuroinflammation in alcohol use and HIV infection: evidence for shared mechanisms. | Monnig MA | — | 2017 | → |
| Neurocognition and inhibitory control in polysubstance use disorders: Comparison with alcohol use disorders and changes with abstinence. | Schmidt TP et al. | — | 2017 | → |
| Structural Neuroimaging in Polysubstance Users. | Meyerhoff DJ | — | 2017 | → |
| White matter alterations in cocaine users are negatively related to the number of additionally (ab)used substances. | Kaag AM et al. | — | 2017 | → |
| Cortical and subcortical gray matter shrinkage in alcohol-use disorders: a voxel-based meta-analysis. | Yang X et al. | — | 2016 | → |
| Volumetric brain abnormalities in polysubstance use disorder patients. | Noyan CO et al. | — | 2016 | → |
| Brain perfusion in polysubstance users: relationship to substance and tobacco use, cognition, and self-regulation. | Murray DE et al. | — | 2015 | → |