Regional brain abnormalities associated with long-term heavy cannabis use.
paper
Cited
Public
Unavailable
- Authors
- YΓΌcel, Murat; Solowij, Nadia; Respondek, Colleen; Whittle, Sarah; Fornito, Alex; Pantelis, Christos; Lubman, Dan I
- Year
- 2008
- Journal
- Archives of general psychiatry
- PMID
- 18519827
- DOI
- 10.1001/archpsyc.65.6.694
CONTEXT: Cannabis is the most widely used illicit drug in the developed world. Despite this, there is a paucity of research examining its long-term effect on the human brain. OBJECTIVE: To determine whether long-term heavy cannabis use is associated with gross anatomical abnormalities in 2 cannabinoid receptor-rich regions of the brain, the hippocampus and the amygdala. DESIGN: Cross-sectional design using high-resolution (3-T) structural magnetic resonance imaging. SETTING: Participants were recruited from the general community and underwent imaging at a hospital research facility. PARTICIPANTS: Fifteen carefully selected long-term (>10 years) and heavy (>5 joints daily) cannabis-using men (mean age, 39.8 years; mean duration of regular use, 19.7 years) with no history of polydrug abuse or neurologic/mental disorder and 16 matched nonusing control subjects (mean age, 36.4 years). MAIN OUTCOME MEASURES: Volumetric measures of the hippocampus and the amygdala combined with measures of cannabis use. Subthreshold psychotic symptoms and verbal learning ability were also measured. RESULTS: Cannabis users had bilaterally reduced hippocampal and amygdala volumes (P = .001), with a relatively (and significantly [P = .02]) greater magnitude of reduction in the former (12.0% vs 7.1%). Left hemisphere hippocampal volume was inversely associated with cumulative exposure to cannabis during the previous 10 years (P = .01) and subthreshold positive psychotic symptoms (P < .001). Positive symptom scores were also associated with cumulative exposure to cannabis (P = .048). Although cannabis users performed significantly worse than controls on verbal learning (P < .001), this did not correlate with regional brain volumes in either group. CONCLUSIONS: These results provide new evidence of exposure-related structural abnormalities in the hippocampus and amygdala in long-term heavy cannabis users and corroborate similar findings in the animal literature. These findings indicate that heavy daily cannabis use across protracted periods exerts harmful effects on brain tissue and mental health.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
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| Abnormal developmental of hippocampal subfields and amygdalar subnuclei volumes in young adults with heavy cannabis use: A three-year longitudinal study. | Zhang X et al. | β | 2025 | β |
| Effects of Cannabis Exposure on Adolescent Health and Development: A Narrative Review. | Li R et al. | β | 2025 | β |
| High-Intensity Exercise and Hippocampal Integrity in Adults With Cannabis Use Disorder: A Randomized Clinical Trial. | Richardson KE et al. | β | 2025 | β |
| Impaired mnemonic pattern separation associated with PTSD symptoms paradoxically improves with regular cannabis use. | Ross J et al. | β | 2025 | β |
| Recent Stress Potentiation and Paralimbic System Reactivity in Young Adults With Bipolar Disorder: Implications for Suicide Risk and Effects of Cannabis Use Disorder. | Bibb N et al. | β | 2025 | β |
| Anti-Ma-Associated Paraneoplastic Syndrome: Imaging Findings Adding to Its Spectrum. | Mustafa F et al. | β | 2024 | β |
| Association between cannabis use and brain structure and function: an observational and Mendelian randomisation study. | Ishrat S et al. | β | 2024 | β |
| Cannabinoids: Role in Neurological Diseases and Psychiatric Disorders. | Kumar U | β | 2024 | β |
| Cannabis in combat sports: position statement of the Association of Ringside Physicians. | Stellpflug SJ et al. | β | 2024 | β |
| Cannabis use disorder contributes to cognitive dysfunction in Veterans with traumatic brain injury. | Esmaeili A et al. | β | 2024 | β |
| Daily Cannabidiol Administration for 10 Weeks Modulates Hippocampal and Amygdalar Resting-State Functional Connectivity in Cannabis Users: A Functional Magnetic Resonance Imaging Open-Label Clinical Trial. | Lorenzetti V et al. | β | 2024 | β |
| Macroscopic and Microscopic Cerebral Findings in Drug and Alcohol Abusers: The Point of View of the Forensic Pathologist. | Montana A et al. | β | 2024 | β |
| Testing a Psychological Intervention in Elite Athletes to Alleviate the Psychomotor Consequences of Doping: The Moderating Role of Personality. | Coli E et al. | β | 2024 | β |
| White matter alterations associated with chronic cannabis use disorder: a structural network and fixel-based analysis. | Maleki S et al. | β | 2024 | β |
| Adolescent Ξ-9-tetrahydrocannabinol exposure induces differential acute and long-term neuronal and molecular disturbances in dorsal vs. ventral hippocampal subregions. | De Felice M et al. | β | 2023 | β |
| Association between cannabis use and brain imaging phenotypes in UK Biobank: an observational and Mendelian randomization study | Ishrat S et al. | β | 2023 | β |
| Brain Anatomical Alterations in Young Cannabis Users: Is it All Hype? A Meta-Analysis of Structural Neuroimaging Studies. | Lorenzetti V et al. | β | 2023 | β |
| Chronic cannabis use and error awareness: The effect on learning from errors. | Dali G et al. | β | 2023 | β |
| Chronic exposure to a synthetic cannabinoid alters cerebral brain metabolism and causes long-lasting behavioral deficits in adult mice. | Bouter C et al. | β | 2023 | β |
| Chronic exposure to inhaled vaporized cannabis high in Ξ9-THC alters brain structure in adult female mice. | Taylor A et al. | β | 2023 | β |
| Effects of inhaled cannabis high in Ξ9-THC or CBD on the aging brain: A translational MRI and behavioral study. | Sadaka AH et al. | β | 2023 | β |
| Impaired Ghrelin Signaling Does Not Lead to Alterations of Anxiety-like Behaviors in Adult Mice Chronically Exposed to THC during Adolescence. | Sestan-Pesa M et al. | β | 2023 | β |
| Perturbed iron biology in the prefrontal cortex of people with schizophrenia. | Lotan A et al. | β | 2023 | β |
| Testing the consequences of alcohol, cannabis, and nicotine use on hippocampal volume: a quasi-experimental cotwin control analysis of young adult twins. | Harper J et al. | β | 2023 | β |
| The economic impact of cannabis use disorder and dementia diagnosis in veterans diagnosed with traumatic brain injury. | Esmaeili A et al. | β | 2023 | β |
| Therapeutic Potential of Cannabis: A Comprehensive Review of Current and Future Applications. | Leinen ZJ et al. | β | 2023 | β |
| Aberrant hippocampal shape development in young adults with heavy cannabis use: Evidence from a longitudinal study. | Xu H et al. | β | 2022 | β |
| Association of Tetrahydrocannabinol Content and Price in Herbal Cannabis Products Offered by Dispensaries in California: A Purview of Consumers/Patients. | Dobbins M et al. | β | 2022 | β |
| Cannabidiol and substance use disorder: Dream or reality. | Karimi-Haghighi S et al. | β | 2022 | β |
| Cannabis Use and Resting State Functional Connectivity in the Aging Brain. | Watson KK et al. | β | 2022 | β |
| Changes in brain structure and function following chronic exposure to inhaled vaporised cannabis during periadolescence in female and male mice: A multimodal MRI study. | Coleman JR et al. | β | 2022 | β |
| Cingulate circuits are associated with escalation of heroin use and naloxone-induced increases in heroin self-administration. | Scarlata MJ et al. | β | 2022 | β |
| How do cannabis users mentally travel in time? Evidence from an fMRI study of episodic future thinking. | Rafei P et al. | β | 2022 | β |
| How do substance use disorders compare to other psychiatric conditions on structural brain abnormalities? A cross-disorder meta-analytic comparison using the ENIGMA consortium findings. | Navarri X et al. | β | 2022 | β |
| Interaction of sex and cannabis in adult <i>in vivo</i> brain imaging studies: A systematic review. | Francis AM et al. | β | 2022 | β |
| Multimodal MRI data fusion reveals distinct structural, functional and neurochemical correlates of heavy cannabis use. | Hirjak D et al. | β | 2022 | β |
| Prefrontal cortex and putamen grey matter alterations in cannabis and tobacco users. | Daniju Y et al. | β | 2022 | β |
| Synaptic changes induced by cannabinoid drugs and cannabis use disorder. | Augustin SM et al. | β | 2022 | β |
| The Link Between Cannabis Use and Violent Behavior in the Early Phase of Psychosis: The Potential Role of Impulsivity. | Moulin V et al. | β | 2022 | β |
| Cannabis Affects Cerebellar Volume and Sleep Differently in Men and Women. | McPherson KL et al. | β | 2021 | β |
| Cannabis Associated Mental Health Effects: A Review. | Kancherla N et al. | β | 2021 | β |
| Cognitive Development and Cannabis Use in Adolescents. | Frolli A et al. | β | 2021 | β |
| Pharmacology and adverse effects of new psychoactive substances: synthetic cannabinoid receptor agonists. | Chung EY et al. | β | 2021 | β |
| Potential and Limits of Cannabinoids in Alzheimer's Disease Therapy. | Abate G et al. | β | 2021 | β |
| Preliminary in vivo evidence of lower hippocampal synaptic density in cannabis use disorder. | D'Souza DC et al. | β | 2021 | β |
| Repetitive transcranial magnetic stimulation as a potential treatment approach for cannabis use disorder. | Kearney-Ramos T et al. | β | 2021 | β |
| Reversing the Psychiatric Effects of Neurodevelopmental Cannabinoid Exposure: Exploring Pharmacotherapeutic Interventions for Symptom Improvement. | De Felice M et al. | β | 2021 | β |
| Sex and dependence related neuroanatomical differences in regular cannabis users: findings from the ENIGMA Addiction Working Group. | Rossetti MG et al. | β | 2021 | β |
| Adolescent cannabinoid exposure interacts with other risk factors in schizophrenia: A review of the evidence from animal models. | Dunn AL et al. | β | 2020 | β |
| Adolescent cannabis use, cognition, brain health and educational outcomes: A review of the evidence. | Lorenzetti V et al. | β | 2020 | β |
| Assessing the Role of Cannabis Use on Cortical Surface Structure in Adolescents and Young Adults: Exploring Gender and Aerobic Fitness as Potential Moderators. | Sullivan RM et al. | β | 2020 | β |
| A Systematic Review of Human Neuroimaging Evidence of Memory-Related Functional Alterations Associated with Cannabis Use Complemented with Preclinical and Human Evidence of Memory Performance Alterations. | Blest-Hopley G et al. | β | 2020 | β |
| Cannabis-Associated Psychotic-like Experiences Are Mediated by Developmental Changes in the Parahippocampal Gyrus. | Yu T et al. | β | 2020 | β |
| Deconstructing the neurobiology of cannabis use disorder. | Ferland JN et al. | β | 2020 | β |
| Editorial: Brain Mediators of the Cannabis-Prodromal Psychosis Connection. | Lange N | β | 2020 | β |
| Impact of Cannabis Use on Brain Structure and Function in Suppressed HIV Infection. | Kallianpur KJ et al. | β | 2020 | β |
| Interaction of Cannabis Use and Aging: From Molecule to Mind. | Yoo HB et al. | β | 2020 | β |
| Interaction of Cannabis Use Disorder and Striatal Connectivity in Antipsychotic Treatment Response. | Blair Thies M et al. | β | 2020 | β |
| Ξ-Tetrahydrocannabinol Increases Dopamine D1-D2 Receptor Heteromer and Elicits Phenotypic Reprogramming in Adult Primate Striatal Neurons. | Hasbi A et al. | β | 2020 | β |
| Alteration to hippocampal volume and shape confined to cannabis dependence: a multi-site study. | Chye Y et al. | β | 2019 | β |
| Anterior cingulate volume reductions in abstinent adolescent and young adult cannabis users: Association with affective processing deficits. | Maple KE et al. | β | 2019 | β |
| A preliminary study of the effects of cannabidiol (CBD) on brain structure in patients with epilepsy. | Sharma AA et al. | β | 2019 | β |
| A regulatory variant of CHRM3 is associated with cannabis-induced hallucinations in European Americans. | Cheng Z et al. | β | 2019 | β |
| Associations between adolescent cannabis use frequency and adult brain structure: A prospective study of boys followed to adulthood. | Meier MH et al. | β | 2019 | β |
| Cannabis effects on brain structure, function, and cognition: considerations for medical uses of cannabis and its derivatives. | Burggren AC et al. | β | 2019 | β |
| Cannabis Use and Consequences. | Mashhoon Y et al. | β | 2019 | β |
| Does regular cannabis use affect neuroanatomy? An updated systematic review and meta-analysis of structural neuroimaging studies. | Lorenzetti V et al. | β | 2019 | β |
| Driving Under the Influence of Cannabis: A Framework for Future Policy. | Chow RM et al. | β | 2019 | β |
| Graduate degree completion: Associations with alcohol and marijuana use before and after enrollment. | Allen HK et al. | β | 2019 | β |
| Grey Matter Volume Differences Associated with Extremely Low Levels of Cannabis Use in Adolescence. | Orr C et al. | β | 2019 | β |
| Harmful Effects of Smoking Cannabis: A Cerebrovascular and Neurological Perspective. | Archie SR et al. | β | 2019 | β |
| HIV infection and age effects on striatal structure are additive. | O'Connor EE et al. | β | 2019 | β |
| Is treated HIV infection still toxic to the brain? | O'Connor E et al. | β | 2019 | β |
| Legalized Cannabis in Colorado Emergency Departments: A Cautionary Review of Negative Health and Safety Effects. | Roberts BA | β | 2019 | β |
| Modulatory effects of cannabinoids on brain neurotransmission. | Cohen K et al. | β | 2019 | β |
| Positive and Negative Effects of Cannabis and Cannabinoids on Health. | Cohen K et al. | β | 2019 | β |
| Regular cannabis use is associated with altered activation of central executive and default mode networks even after prolonged abstinence in adolescent users: Results from a complementary meta-analysis. | Blest-Hopley G et al. | β | 2019 | β |
| The impact of schizophrenia and intelligence on the relationship between age and brain volume. | Jensen MH et al. | β | 2019 | β |
| The neuropsychopharmacology of cannabis: A review of human imaging studies. | Bloomfield MAP et al. | β | 2019 | β |
| Adult consequences of prenatal drug exposure. | Oei JL | β | 2018 | β |
| Associations between adolescent cannabis use and brain structure in psychosis. | Abush H et al. | β | 2018 | β |
| Brain Structural Changes following HIV Infection: Meta-Analysis. | O'Connor EE et al. | β | 2018 | β |
| Cannabinoids in health and disease: pharmacological potential in metabolic syndrome and neuroinflammation. | Mastinu A et al. | β | 2018 | β |
| Cannabis users exhibit increased cortical activation during resting state compared to non-users. | Prashad S et al. | β | 2018 | β |
| Effects of regular cannabis use on neurocognition, brain structure, and function: a systematic review of findings in adults. | Nader DA et al. | β | 2018 | β |
| Episodic foresight deficits in regular, but not recreational, cannabis users. | Mercuri K et al. | β | 2018 | β |
| Larger Gray Matter Volume in the Basal Ganglia of Heavy Cannabis Users Detected by Voxel-Based Morphometry and Subcortical Volumetric Analysis. | Moreno-AlcΓ‘zar A et al. | β | 2018 | β |
| Marijuana Use in the Era of Changing Cannabis Laws: What Are the Risks? Who is Most at Risk? | Stoecker WV et al. | β | 2018 | β |
| Mood Fluctuation and Psychobiological Instability: The Same Core Functions Are Disrupted by Novel Psychoactive Substances and Established Recreational Drugs. | Parrott AC | β | 2018 | β |
| Phytocannabinoids modulate emotional memory processing through interactions with the ventral hippocampus and mesolimbic dopamine system: implications for neuropsychiatric pathology. | Hudson R et al. | β | 2018 | β |
| Problematic alcohol use and hippocampal volume in a female sample: disentangling cause from consequence using a co-twin control study design. | Wilson S et al. | β | 2018 | β |
| Prolonged Cannabidiol Treatment Effects on Hippocampal Subfield Volumes in Current Cannabis Users. | Beale C et al. | β | 2018 | β |
| Subregional Hippocampal Thickness Abnormalities in Older Adults with a History of Heavy Cannabis Use. | Burggren AC et al. | β | 2018 | β |
| Synthetic and Non-synthetic Cannabinoid Drugs and Their Adverse Effects-A Review From Public Health Prospective. | Cohen K et al. | β | 2018 | β |
| Testing associations between cannabis use and subcortical volumes in two large population-based samples. | Gillespie NA et al. | β | 2018 | β |
| The Influence of DAT1, COMT, and BDNF Genetic Polymorphisms on Total and Subregional Hippocampal Volumes in Early Onset Heavy Cannabis Users. | Batalla A et al. | β | 2018 | β |
| The Problem with the Current High Potency THC Marijuana from the Perspective of an Addiction Psychiatrist. | Stuyt E | β | 2018 | β |
| Time to acknowledge the mixed effects of cannabis on health: a summary and critical review of the NASEM 2017 report on the health effects of cannabis and cannabinoids. | Cousijn J et al. | β | 2018 | β |
| Building smart cannabis policy from the science up. | Weiss SRB et al. | β | 2017 | β |
| [Cannabis: A Cognitive Illusion]. | GalvΓ‘n G et al. | β | 2017 | β |
| Cannabis and Depression: A Twin Model Approach to Co-morbidity. | Smolkina M et al. | β | 2017 | β |
| Cannabis-associated psychosis: Neural substrate and clinical impact. | Murray RM et al. | β | 2017 | β |
| Cannabis exacerbates depressive symptoms in rat model induced by reserpine. | Khadrawy YA et al. | β | 2017 | β |
| Cannabis-related hippocampal volumetric abnormalities specific to subregions in dependent users. | Chye Y et al. | β | 2017 | β |
| Discriminative Properties of Hippocampal Hypoperfusion in Marijuana Users Compared to Healthy Controls: ImplicationsΒ for Marijuana AdministrationΒ inΒ Alzheimer's Dementia. | Amen DG et al. | β | 2017 | β |
| Don't Worry, Be Happy: Endocannabinoids and Cannabis at the Intersection of Stress and Reward. | Volkow ND et al. | β | 2017 | β |
| Examining the influence of adolescent marijuana use on adult intelligence: Further evidence in the causation versus spuriousness debate. | Boccio CM et al. | β | 2017 | β |
| Frontal cortex gray matter volume alterations in pathological gambling occur independently from substance use disorder. | Zois E et al. | β | 2017 | β |
| Increased nucleus accumbens volume in first-episode psychosis. | Forns-Nadal M et al. | β | 2017 | β |
| Longitudinal study of hippocampal volumes in heavy cannabis users. | Koenders L et al. | β | 2017 | β |
| Marijuana effects on changes in brain structure and cognitive function among HIV+ and HIV- adults. | Thames AD et al. | β | 2017 | β |
| Orbitofrontal and caudate volumes in cannabis users: a multi-site mega-analysis comparing dependent versus non-dependent users. | Chye Y et al. | β | 2017 | β |
| Potential gray matter unpruned in adolescents and young adults dependent on dextromethorphan-containing cough syrups: evidence from cortical and subcortical study. | Qiu YW et al. | β | 2017 | β |
| Pros and Cons of Medical Cannabis use by People with Chronic Brain Disorders. | Suryadevara U et al. | β | 2017 | β |
| Recreational stimulants, herbal, and spice cannabis: The core psychobiological processes that underlie their damaging effects. | Parrott AC et al. | β | 2017 | β |
| Structural neuroimaging across early-stage psychosis: Aberrations in neurobiological trajectories and implications for the staging model. | Bartholomeusz CF et al. | β | 2017 | β |
| The consequences of chronic cannabis smoking in vulnerable adolescents. | Iede MA et al. | β | 2017 | β |
| The impact of current cannabis use on general cognitive function in people with psychotic illness. | Waterreus A et al. | β | 2017 | β |
| Verbal Learning and Memory in Cannabis and Alcohol Users: An Event-Related Potential Investigation. | Smith JL et al. | β | 2017 | β |
| Ξ9-tetrahydrocannabinol (Ξ9-THC) administration after neonatal exposure to phencyclidine potentiates schizophrenia-related behavioral phenotypes in mice. | RodrΓguez G et al. | β | 2017 | β |
| A Bidirectional Relationship between Executive Function and Health Behavior: Evidence, Implications, and Future Directions. | Allan JL et al. | β | 2016 | β |
| A longitudinal examination of the relationship between cannabis use and cognitive function in mid-life adults. | McKetin R et al. | β | 2016 | β |
| An MRI study of white matter tract integrity in regular cannabis users: effects of cannabis use and age. | Jakabek D et al. | β | 2016 | β |
| A review of vulnerability and risks for schizophrenia: Beyond the two hit hypothesis. | Davis J et al. | β | 2016 | β |
| Association Between Lifetime Marijuana Use and Cognitive Function in Middle Age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. | Auer R et al. | β | 2016 | β |
| Cannabis Use and Associated Harms among Schizophrenia Patients in a Nigerian Clinical Setting: A Case-Control Study. | Lasebikan V et al. | β | 2016 | β |
| Cannabis use and cognitive function in first episode psychosis: differential effect of heavy use. | NΓΊΓ±ez C et al. | β | 2016 | β |
| Effect of high-potency cannabis on corpus callosum microstructure. | Rigucci S et al. | β | 2016 | β |
| Effects of Marijuana Use on Brain Structure and Function: Neuroimaging Findings from a Neurodevelopmental Perspective. | Brumback T et al. | β | 2016 | β |
| Genetic imaging consortium for addiction medicine: From neuroimaging to genes. | Mackey S et al. | β | 2016 | β |
| Grey Matter Changes Associated with Heavy Cannabis Use: A Longitudinal sMRI Study. | Koenders L et al. | β | 2016 | β |
| Hippocampal harms, protection and recovery following regular cannabis use. | YΓΌcel M et al. | β | 2016 | β |
| Joint Effects: A Pilot Investigation of the Impact of Bipolar Disorder and Marijuana Use on Cognitive Function and Mood. | Sagar KA et al. | β | 2016 | β |
| Lifetime use of cannabis from longitudinal assessments, cannabinoid receptor (CNR1) variation, and reduced volume of the right anterior cingulate. | Hill SY et al. | β | 2016 | β |
| Longitudinal predictors of cannabis use and dependence in offspring from families at ultra high risk for alcohol dependence and in control families. | Hill SY et al. | β | 2016 | β |
| Marijuana use trajectories and academic outcomes among college students. | Suerken CK et al. | β | 2016 | β |
| Relation between cannabis use and subcortical volumes in people at clinical high risk of psychosis. | Buchy L et al. | β | 2016 | β |
| Structural imaging for addiction medicine: From neurostructure to neuroplasticity. | Brown GG et al. | β | 2016 | β |
| The effects of cannabis on memory function in users with and without a psychotic disorder: findings from a combined meta-analysis. | Schoeler T et al. | β | 2016 | β |
| The impact of ADHD persistence, recent cannabis use, and age of regular cannabis use onset on subcortical volume and cortical thickness in young adults. | Lisdahl KM et al. | β | 2016 | β |
| The impact of adolescent exposure to medical marijuana laws on high school completion, college enrollment and college degree completion. | Plunk AD et al. | β | 2016 | β |
| The Role of Cannabinoids in Neuroanatomic Alterations in Cannabis Users. | Lorenzetti V et al. | β | 2016 | β |
| Appraising the risks of reefer madness. | Murray R | β | 2015 | β |
| Cannabis and adolescent brain development. | Lubman DI et al. | β | 2015 | β |
| Cannabis and psychopathology: The meandering journey of the last decade. | Ghosh A et al. | β | 2015 | β |
| Cannabis, Cigarettes, and Their Co-Occurring Use: Disentangling Differences in Gray Matter Volume. | Wetherill RR et al. | β | 2015 | β |
| Cannabis-related episodic memory deficits and hippocampal morphological differences in healthy individuals and schizophrenia subjects. | Smith MJ et al. | β | 2015 | β |
| Cannabis: the never-ending, nefarious nepenthe of the 21st century: what should the clinician know? | Greydanus DE et al. | β | 2015 | β |
| Combined effects of marijuana and nicotine on memory performance and hippocampal volume. | Filbey FM et al. | β | 2015 | β |
| Commentary on Hall (2015): The health effects of recreational cannabis use. | Fergusson DM et al. | β | 2015 | β |
| Cortical thinness and volume differences associated with marijuana abuse in emerging adults. | Mashhoon Y et al. | β | 2015 | β |
| Craving is associated with amygdala volumes in adolescent marijuana users during abstinence. | Padula CB et al. | β | 2015 | β |
| Daily marijuana use is not associated with brain morphometric measures in adolescents or adults. | Weiland BJ et al. | β | 2015 | β |
| Effects of marijuana use on prefrontal and parietal volumes and cognition in emerging adults. | Price JS et al. | β | 2015 | β |
| Gross morphological brain changes with chronic, heavy cannabis use. | Lorenzetti V et al. | β | 2015 | β |
| Longitudinal changes in white matter microstructure after heavy cannabis use. | Becker MP et al. | β | 2015 | β |
| Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse. | Korpi ER et al. | β | 2015 | β |
| Preliminary findings demonstrating latent effects of early adolescent marijuana use onset on cortical architecture. | Filbey FM et al. | β | 2015 | β |
| Shared Predisposition in the Association Between Cannabis Use and Subcortical Brain Structure. | Pagliaccio D et al. | β | 2015 | β |
| Stimulants and Cannabis Use Among a Marginalized Population in British Columbia, Canada: Role of Trauma and Incarceration. | Saddichha S et al. | β | 2015 | β |
| Synthetic cannabinoids: the multi-organ failure and metabolic derangements associated with getting high. | Sherpa D et al. | β | 2015 | β |
| Telling true from false: cannabis users show increased susceptibility to false memories. | Riba J et al. | β | 2015 | β |
| The academic consequences of marijuana use during college. | Arria AM et al. | β | 2015 | β |
| What has research over the past two decades revealed about the adverse health effects of recreational cannabis use? | Hall W | β | 2015 | β |
| Brain-derived neurotrophic factor/FK506-binding protein 5 genotype by childhood trauma interactions do not impact on hippocampal volume and cognitive performance. | Hernaus D et al. | β | 2014 | β |
| Brain metabolism in substance-induced psychosis and schizophrenia: a preliminary PET study. | Dragogna F et al. | β | 2014 | β |
| Cannabidiol as a potential treatment for psychosis. | Schubart CD et al. | β | 2014 | β |
| Cannabis and psychosis: Neurobiology. | Shrivastava A et al. | β | 2014 | β |
| Cannabis use is quantitatively associated with nucleus accumbens and amygdala abnormalities in young adult recreational users. | Gilman JM et al. | β | 2014 | β |
| Chronic effects of cannabis use on the auditory mismatch negativity. | Greenwood LM et al. | β | 2014 | β |
| [Clinical prognosis of schizophrenic patients with cannabis addiction. Between nihilism and hope]. | Schnell T | β | 2014 | β |
| Cortical thickness and neurocognition in adolescent marijuana and alcohol users following 28 days of monitored abstinence. | Jacobus J et al. | β | 2014 | β |
| Effects of cannabis on impulsivity: a systematic review of neuroimaging findings. | Wrege J et al. | β | 2014 | β |
| Emergence of new classes of recreational drugs-synthetic cannabinoids and cathinones. | Khullar V et al. | β | 2014 | β |
| Epidemiological, neurobiological, and genetic clues to the mechanisms linking cannabis use to risk for nonaffective psychosis. | van Winkel R et al. | β | 2014 | β |
| Functional connectivity alterations in brain networks relevant to self-awareness in chronic cannabis users. | Pujol J et al. | β | 2014 | β |
| Imaging dopamine transmission parameters in cannabis dependence. | Ghazzaoui R et al. | β | 2014 | β |
| Long-term consequences of adolescent cannabinoid exposure in adult psychopathology. | Renard J et al. | β | 2014 | β |
| Long-term effects of cannabis on brain structure. | Battistella G et al. | β | 2014 | β |
| Long-term effects of marijuana use on the brain. | Filbey FM et al. | β | 2014 | β |
| Modulation of brain structure by catechol-O-methyltransferase Val(158) Met polymorphism in chronic cannabis users. | Batalla A et al. | β | 2014 | β |
| Neurocognitive moderation of associations between cannabis use and psychoneuroticism. | Huijbregts SC et al. | β | 2014 | β |
| Neuropathology of substance use disorders. | Cadet JL et al. | β | 2014 | β |
| Resting state functional magnetic resonance imaging reveals distinct brain activity in heavy cannabis users - a multi-voxel pattern analysis. | Cheng H et al. | β | 2014 | β |
| Structural brain differences in alcohol-dependent individuals with and without comorbid substance dependence. | Mon A et al. | β | 2014 | β |
| The adverse health effects of chronic cannabis use. | Hall W et al. | β | 2014 | β |
| The Cannabis Pathway to Non-Affective Psychosis may Reflect Less Neurobiological Vulnerability. | LΓΈberg EM et al. | β | 2014 | β |
| Worth the wait: effects of age of onset of marijuana use on white matter and impulsivity. | Gruber SA et al. | β | 2014 | β |
| Abnormal maximal finger tapping in abstinent cannabis users. | Flavel SC et al. | β | 2013 | β |
| Alteration to hippocampal shape in cannabis users with and without schizophrenia. | Solowij N et al. | β | 2013 | β |
| [Brain imaging of first-episode psychosis]. | Jardri R | β | 2013 | β |
| Cannabis and psychosis: have we found the missing links? | Parakh P et al. | β | 2013 | β |
| Cannabis use, cognition and brain structure in first-episode psychosis. | Cunha PJ et al. | β | 2013 | β |
| Caudate nucleus-dependent navigational strategies are associated with increased use of addictive drugs. | Bohbot VD et al. | β | 2013 | β |
| Chronic effects of cannabis on sensory gating. | Broyd SJ et al. | β | 2013 | β |
| COMT val158met and 5-HTTLPR genetic polymorphisms moderate executive control in cannabis users. | Verdejo-GarcΓa A et al. | β | 2013 | β |
| Delta-9-tetrahydrocannabinol-induced dopamine release as a function of psychosis risk: 18F-fallypride positron emission tomography study. | Kuepper R et al. | β | 2013 | β |
| Effects of cannabis on neurocognitive functioning: recent advances, neurodevelopmental influences, and sex differences. | Crane NA et al. | β | 2013 | β |
| Functional connectivity and cannabis use in high-risk adolescents. | Houck JM et al. | β | 2013 | β |
| Is cannabis neurotoxic for the healthy brain? A meta-analytical review of structural brain alterations in non-psychotic users. | Rocchetti M et al. | β | 2013 | β |
| Marijuana: current concepts(β ). | Greydanus DE et al. | β | 2013 | β |
| Neuroimaging findings in the at-risk mental state: a review of recent literature. | Wood SJ et al. | β | 2013 | β |
| Pathways from cannabis to psychosis: a review of the evidence. | Burns JK | β | 2013 | β |
| Structural and functional imaging studies in chronic cannabis users: a systematic review of adolescent and adult findings. | Batalla A et al. | β | 2013 | β |
| Tensor-based morphometry of cannabis use on brain structure in individuals at elevated genetic risk of schizophrenia. | Welch KA et al. | β | 2013 | β |
| The effect of cannabis use on memory function: an update. | Schoeler T et al. | β | 2013 | β |
| The endocannabinoid system, cannabinoids, and pain. | Fine PG et al. | β | 2013 | β |
| The myth of schizophrenia as a progressive brain disease. | Zipursky RB et al. | β | 2013 | β |
| The neurobiology of psychopathic traits in youths. | Blair RJ | β | 2013 | β |
| The pharmacologic and clinical effects of medical cannabis. | Borgelt LM et al. | β | 2013 | β |
| Acute intoxication caused by a synthetic cannabinoid in two adolescents. | Heath TS et al. | β | 2012 | β |
| Alterations of theory of mind network activation in chronic cannabis users. | Roser P et al. | β | 2012 | β |
| Applied human psychopharmacology: the practical psychobiological consequences of some novel and ancient psychoactive drugs. | Parrott AC et al. | β | 2012 | β |
| Assessing topographical orientation skills in cannabis users. | Palermo L et al. | β | 2012 | β |
| Associations between cannabinoid receptor-1 (CNR1) variation and hippocampus and amygdala volumes in heavy cannabis users. | Schacht JP et al. | β | 2012 | β |
| Cannabis-related deficits in real-world memory. | Montgomery C et al. | β | 2012 | β |
| [Cannabis: Use and dependence]. | Dervaux A et al. | β | 2012 | β |
| Cannabis use and depression: a longitudinal study of a national cohort of Swedish conscripts. | Manrique-Garcia E et al. | β | 2012 | β |
| Cerebellar grey-matter deficits, cannabis use and first-episode schizophrenia in adolescents and young adults. | Cohen M et al. | β | 2012 | β |
| Chronic adolescent exposure to delta-9-tetrahydrocannabinol in COMT mutant mice: impact on indices of dopaminergic, endocannabinoid and GABAergic pathways. | Behan AT et al. | β | 2012 | β |
| Delayed preattentional functioning in early psychosis patients with cannabis use. | Pesa N et al. | β | 2012 | β |
| Dopamine release in chronic cannabis users: a [11c]raclopride positron emission tomography study. | Urban NB et al. | β | 2012 | β |
| Drugs of abuse and increased risk of psychosis development. | Gururajan A et al. | β | 2012 | β |
| Effect of cannabis use on the course of schizophrenia in male patients: a prospective cohort study. | van Dijk D et al. | β | 2012 | β |
| Effect of long-term cannabis use on axonal fibre connectivity. | Zalesky A et al. | β | 2012 | β |
| Grey matter alterations associated with cannabis use: results of a VBM study in heavy cannabis users and healthy controls. | Cousijn J et al. | β | 2012 | β |
| Legalization, decriminalization & medicinal use of cannabis: a scientific and public health perspective. | Svrakic DM et al. | β | 2012 | β |
| Maternal vitamin C deficiency during pregnancy persistently impairs hippocampal neurogenesis in offspring of guinea pigs. | Tveden-Nyborg P et al. | β | 2012 | β |
| Orbitofrontal volumes in early adolescence predict initiation of cannabis use: a 4-year longitudinal and prospective study. | Cheetham A et al. | β | 2012 | β |
| Reflection impulsivity in adolescent cannabis users: a comparison with alcohol-using and non-substance-using adolescents. | Solowij N et al. | β | 2012 | β |
| Spice drugs are more than harmless herbal blends: a review of the pharmacology and toxicology of synthetic cannabinoids. | Seely KA et al. | β | 2012 | β |
| The 3rd Schizophrenia International Research Society Conference, 14-18 April 2012, Florence, Italy: summaries of oral sessions. | Abbs B et al. | β | 2012 | β |
| The impact of cannabis use on cognitive functioning in patients with schizophrenia: a meta-analysis of existing findings and new data in a first-episode sample. | YΓΌcel M et al. | β | 2012 | β |
| Age at onset of psychotic disorder: cannabis, BDNF Val66Met, and sex-specific models of gene-environment interaction. | Decoster J et al. | β | 2011 | β |
| Age of onset of schizophrenia: perspectives from structural neuroimaging studies. | Gogtay N et al. | β | 2011 | β |
| AKT1 moderation of cannabis-induced cognitive alterations in psychotic disorder. | van Winkel R et al. | β | 2011 | β |
| Are the effects of cannabis dependence on glucose metabolism similar to schizophrenia? An FDG PET understanding. | Parkar SR et al. | β | 2011 | β |
| Cannabis use in young people: the risk for schizophrenia. | Casadio P et al. | β | 2011 | β |
| Cerebellar white-matter changes in cannabis users with and without schizophrenia. | Solowij N et al. | β | 2011 | β |
| Gender effects on amygdala morphometry in adolescent marijuana users. | McQueeny T et al. | β | 2011 | β |
| Greater white and grey matter changes associated with early cannabis use in adolescent-onset schizophrenia (AOS). | James A et al. | β | 2011 | β |
| Medial temporal structures and memory functions in adolescents with heavy cannabis use. | Ashtari M et al. | β | 2011 | β |
| Preliminary evidence for white matter metabolite differences in marijuana-dependent young men using 2D J-resolved magnetic resonance spectroscopic imaging at 4 Tesla. | Silveri MM et al. | β | 2011 | β |
| Reduced cortical thickness as an outcome of differential sensitivity to environmental risks in schizophrenia. | Habets P et al. | β | 2011 | β |
| Reduced striatal volume in cocaine-dependent patients. | BarrΓ³s-Loscertales A et al. | β | 2011 | β |
| Review: The neuropathology of drug abuse. | BΓΌttner A | β | 2011 | β |
| The "new" marijuana. | Wells DL et al. | β | 2011 | β |
| Verbal learning and memory in adolescent cannabis users, alcohol users and non-users. | Solowij N et al. | β | 2011 | β |
| Why so impulsive? White matter alterations are associated with impulsivity in chronic marijuana smokers. | Gruber SA et al. | β | 2011 | β |
| Adolescent cannabis use and psychosis: epidemiology and neurodevelopmental models. | Malone DT et al. | β | 2010 | β |
| Altered parahippocampal functioning in cannabis users is related to the frequency of use. | Becker B et al. | β | 2010 | β |
| Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3T MRI: the impact of medication. | Savitz J et al. | β | 2010 | β |
| Auditory mismatch negativity deficits in long-term heavy cannabis users. | Roser P et al. | β | 2010 | β |
| Cannabis use and progressive cortical thickness loss in areas rich in CB1 receptors during the first five years of schizophrenia. | Rais M et al. | β | 2010 | β |
| Chronic cannabis users show altered neurophysiological functioning on Stroop task conflict resolution. | Battisti RA et al. | β | 2010 | β |
| Chronic use of cannabis and poor neural efficiency in verbal memory ability. | Battisti RA et al. | β | 2010 | β |
| Cognitive function as an emerging treatment target for marijuana addiction. | Sofuoglu M et al. | β | 2010 | β |
| Does cannabis use affect prospective memory in young adults? | Bartholomew J et al. | β | 2010 | β |
| Does dopamine mediate the psychosis-inducing effects of cannabis? A review and integration of findings across disciplines. | Kuepper R et al. | β | 2010 | β |
| Gyrification brain abnormalities associated with adolescence and early-adulthood cannabis use. | Mata I et al. | β | 2010 | β |
| Harms to body and soul--an ideological balancing act for preventing and reducing cannabis use. | Solowij N | β | 2010 | β |
| Hippocampal and caudate volume reductions in antipsychotic-naive first-episode schizophrenia. | Ebdrup BH et al. | β | 2010 | β |
| Hippocampal pathology in individuals at ultra-high risk for psychosis: a multi-modal magnetic resonance study. | Wood SJ et al. | β | 2010 | β |
| Imaging cognitive deficits in drug abuse. | Lundqvist T | β | 2010 | β |
| Insular cortex morphometry in first-episode schizophrenia-spectrum patients: Diagnostic specificity and clinical correlations. | Crespo-Facorro B et al. | β | 2010 | β |
| Long-term consequences of a single treatment of mice with an ultra-low dose of Delta9-tetrahydrocannabinol (THC). | Amal H et al. | β | 2010 | β |
| MDMA (ecstasy) use is associated with reduced BOLD signal change during semantic recognition in abstinent human polydrug users: a preliminary fMRI study. | Raj V et al. | β | 2010 | β |
| Neurochemistry of drug action: insights from proton magnetic resonance spectroscopic imaging and their relevance to addiction. | Licata SC et al. | β | 2010 | β |
| Neuroimaging in cannabis use: a systematic review of the literature. | MartΓn-Santos R et al. | β | 2010 | β |
| Neuropsychological consequences of alcohol and drug abuse on different components of executive functions. | FernΓ‘ndez-Serrano MJ et al. | β | 2010 | β |
| Phytocannabinoids, CNS cells and development: a dead issue? | Downer EJ et al. | β | 2010 | β |
| Structural MRI findings in long-term cannabis users: what do we know? | Lorenzetti V et al. | β | 2010 | β |
| Superior temporal gyrus volume in antipsychotic-naive people at risk of psychosis. | Takahashi T et al. | β | 2010 | β |
| The 2nd Schizophrenia International Research Society Conference, 10-14 April 2010, Florence, Italy: summaries of oral sessions. | Baharnoori M et al. | β | 2010 | β |
| The environment and schizophrenia. | van Os J et al. | β | 2010 | β |
| Adverse health effects of non-medical cannabis use. | Hall W et al. | β | 2009 | β |
| Altered white matter microstructure in adolescent substance users. | Bava S et al. | β | 2009 | β |
| Chronic treatment with Delta(9)-tetrahydrocannabinol impairs spatial memory and reduces zif268 expression in the mouse forebrain. | Boucher AA et al. | β | 2009 | β |
| Diffusion abnormalities in adolescents and young adults with a history of heavy cannabis use. | Ashtari M et al. | β | 2009 | β |
| Insular cortex gray matter changes in individuals at ultra-high-risk of developing psychosis. | Takahashi T et al. | β | 2009 | β |
| Learning and memory deficits in ecstasy users and their neural correlates during a face-learning task. | Roberts GM et al. | β | 2009 | β |
| Midline brain structures in teenagers with first-presentation borderline personality disorder. | Takahashi T et al. | β | 2009 | β |
| N-acetylaspartate (NAA) correlates inversely with cannabis use in a frontal language processing region of neocortex in MDMA (Ecstasy) polydrug users: a 3 T magnetic resonance spectroscopy study. | Cowan RL et al. | β | 2009 | β |
| Prefrontal cortex morphometry in abstinent adolescent marijuana users: subtle gender effects. | Medina KL et al. | β | 2009 | β |
| Psychiatric comorbidities and schizophrenia. | Buckley PF et al. | β | 2009 | β |
| Specific brain structural abnormalities in first-episode schizophrenia. A comparative study with patients with schizophreniform disorder, non-schizophrenic non-affective psychoses and healthy volunteers. | Crespo-Facorro B et al. | β | 2009 | β |
| [Student's use of illicit drugs: a survey in a preventive health service]. | Morvan Y et al. | β | 2009 | β |
| Systematic review and meta-analysis of cannabis treatment for chronic pain. | MartΓn-SΓ‘nchez E et al. | β | 2009 | β |
| Workshop on defining the significance of progressive brain change in schizophrenia: December 12, 2008 American College of Neuropsychopharmacology (ACNP) all-day satellite, Scottsdale, Arizona. The rapporteurs' report. | Borgwardt SJ et al. | β | 2009 | β |