Significant local genetic correlations involving all three phenotypes were observed at two loci. At the first locus (chr4:102,544,804‐104,384,534 containing the BANK1 and SLC39A8 genes; alcohol consumption‐sensation seeking‐ρ g = 0.57, P = 1.90 × 10−5; alcohol consumption‐AUD‐ρ g = 0.46, P = 1.70 × 10−8), follow‐up partial correlation tests, conditioning bivariate correlations on the third phenotype (e.g., sensation seeking‐alcohol consumption‐ρ g partialling out AUD) demonstrated only small changes in association estimates, and a multiple regression model with sensation seeking and AUD predicting alcohol consumption demonstrated a substantial increase in variance explained. These results suggest alcohol consumption is uniquely related to sensation seeking and AUD at this locus (Table 3A). Conversely, at the second locus (chr9:128,785,784‐129,617,771 containing the MVB12B and LMX1B genes; sensation seeking‐alcohol consumption‐ρ g = 0.75, P = 1.13 × 10−10; sensation seeking‐AUD‐ρ g = 0.39, P = 2.53 × 10−7), partial correlation and multiple regression tests demonstrated overlapping associations with sensation seeking, such that alcohol consumption, rather than AUD, was largely responsible for the variance explained in sensation seeking at this locus (Table 3B).
