In total, 47 significant bivariate local genetic correlations were identified among sensation seeking, alcohol consumption, and AUD, following Bonferroni correction (Table S26). Sensation seeking and alcohol consumption were positively correlated across 26 loci (mean ρ g = 0.71). At 14 of these loci, the 95% confidence intervals for the explained variance included 1, suggesting complete overlap of genetic signals. In contrast, sensation seeking was only correlated with AUD across four loci (three positive: ρ g = 0.39–0.46; one negative: ρ g = −0.56). Alcohol consumption and AUD were correlated across 17 loci (16 positive: ρ g = 0.36–0.75; one negative: ρ g = −0.53). None of these confidence intervals of explained variance included 1.
