Pairwise RRHO analyses of H‐MAGMA gene enrichment indicated that overlap of pleiotropic genes between traits was stronger for DA‐midbrain than for dlPFC neurons, particularly for sensation seeking and alcohol consumption, where the number of pleiotropic genes was ~2 times higher in DA‐midbrain than in dlPFC neurons. Visual comparisons of results from pairwise RRHO outputs using heatmaps (Figure 1C) also suggested that the overlap between sensation seeking and alcohol consumption was stronger (Z CN = 16.11; Z DA = 17.85) than the overlap between sensation seeking and AUD (Z CN = 9.47; Z DA = 10.53) and alcohol consumption and AUD (Z CN = 14.20; Z DA = 15.25). This was particularly true for DA‐midbrain neurons where the number of overlapping genes between sensation seeking and alcohol consumption was ~2.5 and ~4.5 times higher than that between sensation seeking and AUD and alcohol consumption and AUD, respectively.
