respectively). For AUD, only a single gene identified by both positional mapping and MAGMA showed H‐MAGMA tissue‐specific enrichment: PDE4B in dlPFC neurons. When looking for overlap across traits (i.e., genes mapped positionally and by MAGMA but to just one H‐MAGMA annotation in relation to two or more traits), only two genes were identified: SEMA6D and RUNX1T1 showed enrichment in DA‐midbrain neurons for both sensation seeking and alcohol consumption.