MAGMA identified 452 genes associated with sensation seeking, 483 with alcohol consumption, and 30 with AUD. H‐MAGMA identified 476 dlPFC and 686 DA‐midbrain tissue‐cell‐type‐specific genes for sensation seeking (Tables S17–S19), 548 dlPFC and 726 DA‐midbrain genes for alcohol consumption (Tables S20–22), and 43 dlPFC and 52 DA‐midbrain genes for AUD (Tables S23–25). When overlapping MAGMA and H‐MAGMA results were restricted to genes that also demonstrated evidence of association via positional mapping of GWS loci, 46 and 43 genes showed enrichment with sensation seeking and alcohol consumption, respectively, across both H‐MAGMA tissue‐cell types (i.e., DA‐midbrain and dlPFC neurons). Three genes (ADH1B, DRD2, and RHOA) showed similar enrichment across tissue‐cell types for AUD. For tissue‐specific results, sensation seeking and alcohol consumption demonstrated greater H‐MAGMA evidence for enrichment in DA‐midbrain (23 and 17 genes, respectively) relative to dlPFC neurons (10 and 7 genes, respectively). For AUD, only a single gene identified by both positional mapping and MAGMA showed H‐MAGMA tissue‐specific enrichment: PDE4B in dlPFC neurons. When looking for overlap across traits (i.e., genes mapped positionally and by MAGMA but to just one H‐MAGMA
