studies by the appropriate boards at their respective institutions: Fred Hutchinson Cancer Research Center Institutional Review Board (WHI), University of North Carolina Office of Human Research Ethics/IRB (OHRE/IRB; HCHS/SOL), University of Southern California IRB (MEC), University of Hawaii IRB (MEC), Icahn School of Medicine at Mount Sinai IRB (BioMe) and the Stanford University IRB (GRP). Additional information about each participating study can be found in the Supplementary Information.