Effects of EtOH on LTP have been studied in different brain regions, but the majority of information comes from studies of the Schaffer collateral inputs to the CA1 pyramidal neurons of the hippocampal formation (Blitzer et al. 1990; Morrisett and Swartzwelder 1993; Mulkeen et al. 1987; Sinclair and Lo 1986). Acute EtOH exposure generally suppresses the induction of LTP at this and other synapses (Yin et al. 2007; Blitzer et al. 1990; Givens and McMahon 1995; Morrisett and Swartzwelder 1993; Mulkeen et al. 1987; Sinclair and Lo 1986; Wayner et al. 1993; Weitlauf et al. 2004). Effects occur at EtOH concentrations associated with intoxication, and in some studies at surprisingly low concentrations (Blitzer et al. 1990; Fujii et al. 2008). EtOH also inhibits LTP induced by kainate receptor activation in the basolateral amygdala (Lack et al. 2008).
