There is not as much information regarding EtOH effects on LTD. Two prominent subtypes of LTD can be elicited in the hippocampal CA1 region. The most widely studied form of LTD is induced by repetitive low-frequency synaptic activation, and requires activation of NMDA receptors (Dudek and Bear 1992; Mulkey and Malenka 1992). In the hippocampal CA1 region LTD is enhanced by exposure to EtOH at a concentration associated with strong intoxication (Hendricson et al. 2002), although this observation has not been consistent (Izumi et al. 2005).
