of hippocampal neurons110, which has been confirmed by cell-attached patch-clamp recordings111. In addition to the shaft, immuno-gold labeling show a tight association of GIRK channels and GABAB receptors on dendritic spines110. In the cerebellum, immunoelectron microscopy studies show that GIRK2/GIRK3 channels are localized in the postsynaptic density, while GIRK1/GIRK3 channels are perisynaptic112. It is tempting to speculate that the subcellular localization may correlate with the Gβγ affinity (GIRK2/GIRK3; lower EC50) in neurons.
