Future immunoelectron or super-resolution microscopy studies may reveal additional details on the localization of GIRK channels, GABAB receptors, RGS and G proteins in neurons, that provide further insights into their function. Discussions concerning the existence of a GIRK macromolecular signaling complex in vivo still continue, however. Additional studies will need to clarify the role of collision coupling and whether changes in GIRK signaling occur at the level of the GPCR/GIRK macromolecular complex or individual components in the signaling pathway.
