The physiological activation of GIRK channels can shape the neuronal network behavior in many areas of the brain at different levels. The basal activity of GIRK channels contributes to the resting potential of neurons, shifting the membrane voltage by ~−8 mV27. This hyperpolarization of the resting membrane potential decreases electrical excitability. In addition, receptor activation of GIRK channels provides another level of inhibition, to which three different changes in signaling can be generally ascribed.
