Chunk #22 — Results — Drug-Free Genotype Differences—Stop Task

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Evaluation of genetic variability in the dopamine receptor D2 in relation to behavioral inhibition and impulsivity/sensation seeking: an exploratory study with d-amphetamine in healthy participants.

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Four haplotypes (TAAG, CCGA, TAAA, and CCAA) constructed from rs4648317, rs4350392, rs1799978, and rs12364283, were assessed for association with stop and go RTs. Haplotype TAAG was associated with faster stop RT (p = .005, indicating lower impulsivity) and remained significant after adjusting for multiple testing (p = .02). Haplotype CCAA was associated with slower stop RT (p = .008) and remained significant after adjusting for multiple testing (p = .03). (See Table 4 for the mean stop RT values for each haplotype.) Haplotypes in Block 1 were not associated with stop RT. None of the haplotypes (in Block 1 or Block 2) were associated with go RT.