Chunk #21 — Results — Drug-Free Genotype Differences—Stop Task

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Evaluation of genetic variability in the dopamine receptor D2 in relation to behavioral inhibition and impulsivity/sensation seeking: an exploratory study with d-amphetamine in healthy participants.

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Genotypic groups of three SNPs (rs4648317, rs4350392, and rs12364283—all in Haplotype Block 2) had significantly different stop RTs (see Table 3). The remaining SNPs in the analysis were not associated with stop RT. The most significantly associated SNP, rs12364283, had a p value of .005. After correcting for testing all 12 SNPs, the p value remained significant at .035 (see Table 4). None of the DRD2 loci included in this study were associated with go RT.