Second, we found distinct DMN connectivity patterns that separated patients with mTLE from healthy controls, in that controls showed greater posterior interhemispheric DMN and patients with mTLE greater anterior intrahemispheric DMN connectivity. Interestingly, virtual lesion models predicted these patterns in that damage to virtual DMN nodes results in widespread decreased interhemispheric and increased intrahemispheric connectivity (Alstott et al., 2009). Although not affecting the DMN directly, in line with this idea is a recent study showing that complete surgical separation of the two hemispheres in monkeys not only disrupted interhemispheric connectivity as expected but also increased intrahemispheric connectivity (O'Reilly et al., 2013). In mTLE, previous studies report mostly reduced functional connectivity to the damaged MTL, however, a growing number of studies also report increases of functional connectivity but these are inconsistent regarding the location and extent (McCormick et al., 2013a; Voets et al., 2014; Bettus et al., 2010; Maccotta et al., 2013; Morgan et al., 2011). One major difference between ours and previous studies is that they typically used single seed-based analysis whereas we used a multivariate pattern analysis that allowed
