et al., 2014; Bettus et al., 2010; Maccotta et al., 2013; Morgan et al., 2011). One major difference between ours and previous studies is that they typically used single seed-based analysis whereas we used a multivariate pattern analysis that allowed us to examine altered patterns throughout but specific to DMN connectivity. That is, the specification of a single seed, for example, the damaged or contralateral medial temporal lobe, only examines a subset of DMN connections, i.e., from the medial temporal lobe to all other regions of the DMN. This approach might obscure effects of extra-MTL connections within the DMN, such as the pattern we identified in patients with mTLE. On the other hand, whole brain analysis (for example, independent component analysis, ICA) might obscure effects specific to the DMN (but see Voets et al., 2012 for an exception).
