One of the main advantages of this study is the combination of techniques which each have superior spatial and temporal resolution, respectively. Thus, we investigate pathological craving after 24 hours of alcohol abstinence from two different angles. The first is to understand the changes in spontaneous activity and functional connectivity. The second is to understand the changes in activity and functional connectivity in response to alcoholic and non-alcoholic cues. The superior spatial resolution of fMRI helps us investigate deeper structures and their relevance to pathological craving in alcohol dependence on exposure to alcohol-related cues. Conversely, the superior temporal resolution of EEG helps us to understand the changes in different frequency bands. The combination of these two techniques in the same patients gives us a more comprehensive view of pathological craving and the functional networks that may encode it. Thus, from the results of the current study we observe that different cortical and subcortical regions are involved in encoding different aspects of substance craving. The incentive salience encoded by the dACC is characteristic of “give me more”, which is not suppressed
