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Chunk #15 — 2. Materials and Methods — 2.1 Identification of human phenotypes and QTLs

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A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models.
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Most studies that have conducted linkage analyses for alcohol related traits have used DSM based alcohol dependence as the phenotype of interest. However, there have also been genome screens conducted on a number of other alcohol-related traits including: number of dependence symptoms (Ehlers et al., 2004), alcohol withdrawal severity (Ehlers et al., 2004), antisocial or conduct disorder symptoms or traits co-occurring with alcohol dependence (Dick et al., 2004; Kendler et al., 2006; Ehlers et al., 2008), personality factors co-occurring with alcohol dependence (Nurnberger et al., 2001; Dick et al., 2002), maximum drinks in 24 hours (Saccone et al., 2000), craving for alcohol (Ehlers and Wilhelmsen, 2005; Foroud et al., 2007), alcohol and tobacco usage (Ehlers and Wilhelmsen, 2006), latent class analyses of alcohol abuse and other related phenotypes (Foroud et al., 1998), low response to alcohol (Wilhelmsen et al., 2003; Schuckit et al., 2005), and alcohol dependence with EEG correlates (Porjesz et al., 2002). For the purposes of the present set of analyses, we selected areas in the genome linked to any alcohol-related phenotypes where there was convergent evidence from