paperKB
coga / coga-kb
Processing
Help
Sign in

Chunk #16 — 2. Materials and Methods — 2.1 Identification of human phenotypes and QTLs

Source
A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models.
Embedded
yes

Text

Schuckit et al., 2005), and alcohol dependence with EEG correlates (Porjesz et al., 2002). For the purposes of the present set of analyses, we selected areas in the genome linked to any alcohol-related phenotypes where there was convergent evidence from at least two studies for QTL(s) within 50 cM with a relatively high level of statistical confidence in linkage (log of the odds of linkage [LOD] scores greater than 1.5). Initially, regions were identified using data from the following studies: COGA, SW Indian family study, Mission Indian family study, Pittsburgh family study, Irish Sib-Pair study, smoking behavior sample, and the Framingham study.