very small subset of genes with theoretical biological import, such as DRD2/ANKK1, 41 , 42 , 43 HTT, 44 , 45 , 46 OPRK1 and PDYN, 41 , 47 , 48 , 49 ACN9, 50 NFKB1, 51 tachykinin receptor 3, 52 GABRR1 and GABRR2, 53 CRHR1, 33 SGIP1, 54 CHRNA5, 55 NPY 56 (emerging from rodent eQTL studies of ethanol preference 57 , 58 , 59 ) and SNCA. 60 Leveraging the family‐based design, COGA association analyses typically followed pedigree disequilibrium tests rather than the conventional case–control design.
