COGA was among the first studies to pursue GWAS genotyping, first for diagnostic and then, increasingly, for quantitative traits. This shift reflected, in part, the growing recognition that genes of large effect were likely to be the exception rather than the norm for complex traits like AUD, and that GWAS approaches would be necessary to elucidate the many genes and variants of individually small effect sizes contributing to disorders. The remainder of this review delves into GWAS‐based analyses of our richly characterized pedigrees.
