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Chunk #31 — Discussion

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The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies.
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In contrast, we did show a significant relationship between 5HTT mRNA expression and lifetime history of AD. This is consistent with some theories on the pathogenesis of AD [Enoch, 2003; Kaufman et al., 2007]. Still, we note that we have not corrected our analyses of the clinical phenotypes for multiple comparisons. Hence, these findings with respect to AD should be viewed cautiously.