Genome-wide rgs between psychotic disorders and cannabis phenotypes range from 0.22, for BIP and CUD, to 0.35, for SCZ and CUD (Figure 2A). Local rgs, which give a more granular picture of genetic overlap in the presence of mixed effect directions, showed that on average only 65% of nominally significant local rgs were in the positive direction between each psychotic-cannabis phenotype pair (Supplementary Table 3). Therefore, in Figure 2B, a mixture of negative (i.e., blue points) and positive (i.e., red points) local rgs were observed for each psychotic-cannabis phenotype pair.
