Chunk #18 — Materials and Methods — Linkage disequilibrium

Source

Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.

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The dependence of allele frequencies at two loci is called linkage disequilibrium (LD) (Lonjou et al., 2003). D’(the value of LD normalized to the highest observable value between the two loci considered) values for pairwise LD of CNR1 markers were calculated and visualized through the program haploview v3.32 (Barrett et al 2005).