mediating cocaine induction of H3S10 phosphorylation [56]. Interestingly, despite several control gene promoters where acute cocaine does not affect histone acetylation (β-tubulin, tyrosine hydroxylase, histone H4) [53], acute cocaine does increase global levels of histone H4 acetylation and histone H3 phospho-acetylation, but not H3 acetylation alone within 30 minutes [53, 55]. Thus, global changes in histone modifications, which have been observed in learning models and in response to environmental enrichment [57, 58], may be accounted for by altered acetylation at a specific subset of genes.
