Histone acetylation in drug addiction.

paper Cited Public

Authors: Renthal, William; Nestler, Eric J
Year: 2009
Journal: Seminars in cell & developmental biology
PMID: 19560043
DOI: 10.1016/j.semcdb.2009.01.005
PMCID: PMC2704458

#	Section	Preview
0	Introduction	Drug addiction is a chronic psychiatric condition of compulsive drug seeking and taking despite…
1	Introduction	limbic structures to synthesize the appropriate synaptic and behavioral responses to rewarding…
2	Introduction	genome-wide studies begin to illustrate the potent regulatory control drugs of abuse have on gene…
3	Introduction	A key cellular mechanism that integrates diverse environmental stimuli with changes in gene…
4	Introduction	either physically relax (e.g. histone acetylation) or remodel (e.g. SWI-SNF-dependent nucleosome…
5	Histone Acetylation	Histone acetylation occurs on histones H2A, H2B, H3, and H4, but it is best described in brain on H3…
6	Histone Acetylation	recruit other components of the transcriptional machinery, including RNA polymerase, which…
7	Histone Acetylation	Histone acetylation is highly regulated by two families of enzymes: HATs, as mentioned earlier, and…
8	Histone Acetylation	HATs are divided into three main families, GNAT (Gcn5-related N-acetyltransferase), MYST…
9	Histone Acetylation	retardation and other abnormalities [20]. CBP and p300 are distinct proteins but often referred to…
10	Histone Acetylation	HDACs are divided into four distinct classes based on their homology to the yeast proteins rpd3…
11	Histone Acetylation	highly regulated through post-translational modifications that control their activity, subcellular…
12	Histone Acetylation	Together, the large families of HATs and HDACs integrate a wide range of extracellular signals to…
13	Drug-Induced Changes in Histone Acetylation — Cocaine/Amphetamine	Cocaine and amphetamine substantially elevate dopamine levels in several forebrain regions involved…
14	Drug-Induced Changes in Histone Acetylation — Cocaine/Amphetamine	Acute exposure to cocaine or amphetamine, for example, which are known to rapidly induce the…
15	Drug-Induced Changes in Histone Acetylation — Cocaine/Amphetamine	mediating cocaine induction of H3S10 phosphorylation [56]. Interestingly, despite several control…
16	Drug-Induced Changes in Histone Acetylation — Cocaine/Amphetamine	The induction of immediate early genes such as c-fos by cocaine or amphetamine after repeated drug…
17	Drug-Induced Changes in Histone Acetylation — Cocaine/Amphetamine	(neuropeptide Y) expression was found to be upregulated and its gene promoter hyperacetylated, while…
18	Drug-Induced Changes in Histone Acetylation — Ethanol and other drugs of abuse	Ethanol, a central nervous system depressant, is one of the most widely available and commonly…
19	Drug-Induced Changes in Histone Acetylation — Ethanol and other drugs of abuse	In Drosophila, changes in histone acetylation have also been implicated in the molecular and…

Citation	PMID	DOI	Status
Alarcon, JM et al., Neuron, 2004, Chromatin acetylation, memory, and LTP are impaired in CBP+/− mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration	15207239	10.1016/j.neuron.2004.05.021	Cited
Berton, O et al., Science, 2006, Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress	16469931	10.1126/science.1120972	Cited
Bibb, JA et al., Nature, 2001, Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5	11268215	10.1038/35066591	Cited
Brami-Cherrier, K et al., J Neurosci, 2005, Parsing molecular and behavioral effects of cocaine in mitogen- and stress-activated protein kinase-1-deficient mice	16339038	10.1523/JNEUROSCI.1711-05.2005	Cited
Burley, SK et al., Annu Rev Biochem, 1996, Biochemistry and structural biology of transcription factor IID (TFIID)	8811195	10.1146/annurev.bi.65.070196.004005	Cited
Candido, EP et al., Cell, 1978, Sodium butyrate inhibits histone deacetylation in cultured cells	667927	10.1016/0092-8674(78)90305-7	Cited
Carle, TL et al., Eur J Neurosci, 2007, Proteasome-dependent and -independent mechanisms for FosB destabilization: identification of FosB degron domains and implications for DeltaFosB stability	17561814	10.1111/j.1460-9568.2007.05575.x	Cited
Carlezon, WA et al., Science, 1998, Regulation of cocaine reward by CREB	9856954	10.1126/science.282.5397.2272	Cited
Chawla, S et al., J Neurochem, 2003, Neuronal activity-dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5	12641737	10.1046/j.1471-4159.2003.01648.x	Cited
Chrivia, JC et al., Nature, 1993, Phosphorylated CREB binds specifically to the nuclear protein CBP	8413673	10.1038/365855a0	Cited
Colby, CR et al., J Neurosci, 2003, Striatal cell type-specific overexpression of DeltaFosB enhances incentive for cocaine	12657709	10.1523/JNEUROSCI.23-06-02488.2003	Cited
Doi, M et al., Cell, 2006, Circadian regulator CLOCK is a histone acetyltransferase	16678094	10.1016/j.cell.2006.03.033	Cited
Etchegaray, JP et al., Nature, 2003, Rhythmic histone acetylation underlies transcription in the mammalian circadian clock	12483227	10.1038/nature01314	Cited
Felsenfeld, G et al., Nature, 2003, Controlling the double helix	12540921	10.1038/nature01411	Cited
Fischer, A et al., Nature, 2007, Recovery of learning and memory is associated with chromatin remodelling	17468743	10.1038/nature05772	Cited
Fischle, W et al., Mol Cell, 2002, Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR	11804585	10.1016/s1097-2765(01)00429-4	Cited
Freeman, WM et al., J Neurochem, 2001, Chronic cocaine-mediated changes in non-human primate nucleus accumbens gene expression	11299316	10.1046/j.1471-4159.2001.00252.x	Cited
Freeman, WM et al., Neuropsychopharmacology, 2007, Persistent alterations in mesolimbic gene expression with abstinence from cocaine self-administration	17851536	10.1038/sj.npp.1301577	Cited
Ghezzi, A et al., Proc Natl Acad Sci U S A, 2004, slo K(+) channel gene regulation mediates rapid drug tolerance	15569939	10.1073/pnas.0405584101	Cited
Grimm, JW et al., J Neurosci, 2003, Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving	12574402	10.1523/JNEUROSCI.23-03-00742.2003	Cited
Hubbert, C et al., Nature, 2002, HDAC6 is a microtubule-associated deacetylase	12024216	10.1038/417455a	Cited
Hyman, SE et al., Annu Rev Neurosci, 2006, Neural mechanisms of addiction: the role of reward-related learning and memory	16776597	10.1146/annurev.neuro.29.051605.113009	Cited
Jacobson, RH et al., Science, 2000, Structure and function of a human TAFII250 double bromodomain module	10827952	10.1126/science.288.5470.1422	Cited
Kalda, A et al., Behav Brain Res, 2007, Histone deacetylase inhibitors modulates the induction and expression of amphetamine-induced behavioral sensitization partially through an associated learning of the environment in mice	17477979	10.1016/j.bbr.2007.03.027	Cited
Kalivas, PW et al., Neuron, 2005, Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission	15748840	10.1016/j.neuron.2005.02.005	Cited
Kalivas, PW, Curr Opin Pharmacol, 2004, Glutamate systems in cocaine addiction	15018835	10.1016/j.coph.2003.11.002	Cited
Kawaguchi, Y et al., Cell, 2003, The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress	14675537	10.1016/s0092-8674(03)00939-5	Cited
Kelley, AE et al., J Neurosci, 2002, The neuroscience of natural rewards: relevance to addictive drugs	11978804	10.1523/JNEUROSCI.22-09-03306.2002	Cited
Kelz, MB et al., Nature, 1999, Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine	10499584	10.1038/45790	Cited
Kim, JE et al., Nature, 2008, DBC1 is a negative regulator of SIRT1	18235501	10.1038/nature06500	Cited
Koob, G et al., Am J Psychiatry, 2007, Stress, dysregulation of drug reward pathways, and the transition to drug dependence	17671276	10.1176/appi.ajp.2007.05030503	Cited
Korzus, E et al., Neuron, 2004, CBP histone acetyltransferase activity is a critical component of memory consolidation	15207240	10.1016/j.neuron.2004.06.002	Cited
Kouzarides, T, Cell, 2007, Chromatin modifications and their function	17320507	10.1016/j.cell.2007.02.005	Cited
Kouzarides, T, EMBO J, 2000, Acetylation: a regulatory modification to rival phosphorylation?	10716917	10.1093/emboj/19.6.1176	Cited
Kumar, A et al., Neuron, 2005, Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum	16242410	10.1016/j.neuron.2005.09.023	Cited
Kumar, A et al., Soc Neurosci Abs, 2007, Genome-wide epigenetic changes underlying chronic cocaine-induced neuroadaptations in the mouse nucleus accumbens	—	—	—
Kurdistani, SK et al., Cell, 2004, Mapping global histone acetylation patterns to gene expression	15186774	10.1016/j.cell.2004.05.023	Cited
Lahm, A et al., Proc Natl Acad Sci U S A, 2007, Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases	17956988	10.1073/pnas.0706487104	Cited
Lee, H et al., Mol Cell Biol, 2004, Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A	14701748	10.1128/MCB.24.2.765-773.2004	Cited
Levenson, JM et al., J Biol Chem, 2004, Regulation of histone acetylation during memory formation in the hippocampus	15273246	10.1074/jbc.M402229200	Cited
Levine, AA et al., Proc Natl Acad Sci U S A, 2005, CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatum	16380431	10.1073/pnas.0509735102	Cited
Li, B et al., Cell, 2007, The role of chromatin during transcription	17320508	10.1016/j.cell.2007.01.015	Cited
Li, F et al., Nucleic Acids Res, 2007, Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes	17151075	10.1093/nar/gkl1035	Cited
Lo, WS et al., Mol Cell, 2000, Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14	10911986	10.1016/s1097-2765(00)80257-9	Cited
Lobo, IA et al., Pharmacol Biochem Behav, 2008, GABA(A) receptors and alcohol	18423561	10.1016/j.pbb.2008.03.006	Cited
Lobo, MK et al., Nat Neurosci, 2006, FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains	16491081	10.1038/nn1654	Cited
Luger, K et al., Curr Opin Genet Dev, 1998, The histone tails of the nucleosome	9610403	10.1016/s0959-437x(98)80134-2	Cited
Mahadev, K et al., Neurochem Res, 1998, Effect of ethanol on chromatin and nonhistone nuclear proteins in rat brain	9712188	10.1023/a:1020778018149	Cited
Marmorstein, R, Cell Mol Life Sci, 2001, Structure and function of histone acetyltransferases	11437231	10.1007/PL00000893	Cited
McClung, C et al., Mol Brain Res, 2003, DeltaFosB: a molecular switch for long-term adaptation in the brain	15582154	10.1016/j.molbrainres.2004.05.014	Cited
McClung, CA et al., J Neurosci, 2005, Regulation of gene expression by chronic morphine and morphine withdrawal in the locus ceruleus and ventral tegmental area	15976090	10.1523/JNEUROSCI.0062-05.2005	Cited
McClung, CA et al., Nat Neurosci, 2003, Regulation of gene expression and cocaine reward by CREB and DeltaFosB	14566342	10.1038/nn1143	Cited
McKinsey, T et al., Proc Natl Acad Sci U S A, 2000, Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5	11114197	10.1073/pnas.260501497	Cited
Michan, S et al., Biochem J, 2007, Sirtuins in mammals: insights into their biological function	17447894	10.1042/BJ20070140	Cited
Nestler, EJ, Nat Rev Neurosci, 2001, Molecular basis of long-term plasticity underlying addiction	11252991	10.1038/35053570	Cited
Pandey, SC et al., J Neurosci, 2008, Brain chromatin remodeling: a novel mechanism of alcoholism	18385331	10.1523/JNEUROSCI.5731-07.2008	Cited
Pokholok, DK et al., Cell, 2005, Genome-wide map of nucleosome acetylation and methylation in yeast	16122420	10.1016/j.cell.2005.06.026	Cited
Rashid, AJ et al., Proc Natl Acad Sci U S A, 2007, D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum	17194762	10.1073/pnas.0604049104	Cited
Renthal, W et al., J Neurosci, 2008, DeltaFosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure	18632938	10.1523/JNEUROSCI.1043-08.2008	Cited
Renthal, W et al., Neuron, 2007, Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli	17988634	10.1016/j.neuron.2007.09.032	Cited
Renthal, W et al., Soc Neurosci Abs, 2008, Histone deacetylase 5 controls analgesic responsiveness to tricyclic antidepressants in a mouse model of neurophatic pain	—	—	—
Richon, VM et al., Proc Natl Acad Sci U S A, 1998, A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases	9501205	10.1073/pnas.95.6.3003	Cited
Schroeder, FA et al., Biol Psychiatry, 2007, Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse	16945350	10.1016/j.biopsych.2006.06.036	Cited
Schroeder, FA et al., Neuropsychopharmacology, 2008, Drug-induced activation of dopamine D(1) receptor signaling and inhibition of class I/II histone deacetylase induce chromatin remodeling in reward circuitry and modulate cocaine-related behaviors	18288092	10.1038/npp.2008.15	Cited
Sengupta, N et al., J Cell Biochem, 2004, Regulation of histone deacetylase activities	15352162	10.1002/jcb.20179	Cited
Smith, AE et al., J Biol Chem, 2008, Heritable gene repression through the action of a directed DNA methyltransferase at a chromosomal locus	18272522	10.1074/jbc.M710393200	Cited
Stipanovich, A et al., Nature, 2008, A phosphatase cascade by which rewarding stimuli control nucleosomal response	18496528	10.1038/nature06994	Cited
Strahl, BD et al., Nature, 2000, The language of covalent histone modifications	10638745	10.1038/47412	Cited
Tsankova, N et al., Nat Neurosci, 2006, Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action	16501568	10.1038/nn1659	Cited
Tsankova, N et al., Nat Rev Neurosci, 2007, Epigenetic regulation in psychiatric disorders	17453016	10.1038/nrn2132	Cited
Tsankova, NM et al., J Neurosci, 2004, Histone modifications at gene promoter regions in rat hippocampus after acute and chronic electroconvulsive seizures	15201333	10.1523/JNEUROSCI.0589-04.2004	Cited
Ulery, PG et al., J Neurosci, 2006, Regulation of DeltaFosB stability by phosphorylation	16687504	10.1523/JNEUROSCI.4970-05.2006	Cited
Vannini, A et al., Proc Natl Acad Sci U S A, 2004, Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor	15477595	10.1073/pnas.0404603101	Cited
Walters, CL et al., J Neurosci, 2001, Different requirements for cAMP response element binding protein in positive and negative reinforcing properties of drugs of abuse	11717377	10.1523/JNEUROSCI.21-23-09438.2001	Cited
Wang, Y et al., PLoS Biol, 2007, Drug-induced epigenetic changes produce drug tolerance	17941717	10.1371/journal.pbio.0050265	Cited
Winstanley, CA et al., J Neurosci, 2007, DeltaFosB induction in orbitofrontal cortex mediates tolerance to cocaine-induced cognitive dysfunction	17898221	10.1523/JNEUROSCI.2566-07.2007	Cited
Wood, MA et al., Learn Mem, 2005, Transgenic mice expressing a truncated form of CREB-binding protein (CBP) exhibit deficits in hippocampal synaptic plasticity and memory storage	15805310	10.1101/lm.86605	Cited
Wood, MA et al., Learn Mem, 2006, A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes	16980541	10.1101/lm.213906	Cited
Xu, W et al., Mol Cell Biol, 1998, Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates	9742083	10.1128/mcb.18.10.5659	Cited
Yang, XJ et al., Nat Rev Mol Cell Biol, 2008, The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men	18292778	10.1038/nrm2346	Cited
Yao, WD et al., Neuron, 2004, Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity	14980210	10.1016/s0896-6273(04)00048-0	Cited
Yoshida, M et al., J Biol Chem, 1990, Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A	2211619	—	Cited
Yuferov, V et al., Addict Biol, 2005, Microarray studies of psychostimulant-induced changes in gene expression	15849024	10.1080/13556210412331308976	Cited
Yuferov, V et al., Synapse, 2003, Differential gene expression in the rat caudate putamen after “binge” cocaine administration: advantage of triplicate microarray analysis	12687634	10.1002/syn.10198	Cited
Zachariou, V et al., Nat Neurosci, 2006, An essential role for DeltaFosB in the nucleus accumbens in morphine action	16415864	10.1038/nn1636	Cited
Zhang, C et al., Cell, 2002, Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy	12202037	10.1016/s0092-8674(02)00861-9	Cited
Zhao, W et al., Nature, 2008, Negative regulation of the deacetylase SIRT1 by DBC1	18235502	10.1038/nature06515	Cited

In this knowledge base

Title	Year	PMID
Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity.	2012	22841890
Genetic research: who is at risk for alcoholism.	2010	23579937

External

Title	Authors	Journal	Year	Link
The effects of alcohol dependence on the CSF proteome in mice: Evidence for blood-brain barrier dysfunction and neuroinflammation.	Turner NP et al.	—	2026	→
BK channels and alcohol tolerance: Insights from studies on <i>Drosophila</i>, nematodes, rodents and cell lines: A systematic review.	Ignat LA et al.	—	2025	→
CREB-Binding Protein Regulates Cocaine- and Amphetamine-Regulated Transcript Peptide Expression in the Lateral Hypothalamus: Implication in Reward and Reinforcement.	Pawar N et al.	—	2025	→
Decoding Encoded Cravings: Epigenetic Drivers of Addiction.	Hediyal TA et al.	—	2025	→
Epigenetic regulation of cocaine intake through dopaminergic control of cholinergic interneurons in male mice.	Lewis RG et al.	—	2025	→
Histone deacetylase inhibitor sodium butyrate increases risk-taking during acquisition of the rat gambling task.	Hrelja KM et al.	—	2025	→
The clinical use of epigenetics in psychiatry: a narrative review of epigenetic mechanisms, key candidate genes, and precision psychiatry.	Montel Hayes R et al.	—	2025	→
The effects of Alcohol Dependence on the CSF Proteome in Mice: Evidence for Blood-Brain Barrier Dysfunction and Neuroinflammation	Turner NP et al.	—	2025	—
How life events may confer vulnerability to addiction: the role of epigenetics.	Liu SX et al.	—	2024	→
"More stress, more addiction?" The relationship between stress and relapse of male individuals with drug addiction: A chain mediation model.	Guo H et al.	—	2024	→
Epigenetic Effects of Psychoactive Drugs.	Ahmed R et al.	—	2023	→
Exosomal miRNAs in the Tumor Microenvironment of Multiple Myeloma.	Alipoor SD et al.	—	2023	→
Identification of Potential Genes and Critical Pathways in Postoperative Recurrence of Crohn's Disease by Machine Learning And WGCNA Network Analysis.	Rajalingam A et al.	—	2023	→
Morphine-withdrawal aversive memories and their extinction modulate H4K5 acetylation and Brd4 activation in the rat hippocampus and basolateral amygdala.	Franco-García A et al.	—	2023	→
Histone modifications in neurodifferentiation of embryonic stem cells.	Huang M et al.	—	2022	→
JQ1 attenuates psychostimulant- but not opioid-induced conditioned place preference.	Babigian CJ et al.	—	2022	→
Multiple Myeloma: Challenges Encountered and Future Options for Better Treatment.	Das S et al.	—	2022	→
Sex Differences in Psychostimulant Abuse: Implications for Estrogen Receptors and Histone Deacetylases.	Torres OV	—	2022	→
Comparison of the sensitizing effects of cocaine and ethanol on histone deacetylase isoforms in the rat brain.	Xu S et al.	—	2021	→
Effect of histone acetylation on maintenance and reinstatement of morphine-induced conditioned place preference and ΔFosB expression in the nucleus accumbens and prefrontal cortex of male rats.	Saberian H et al.	—	2021	→
Epigenetic Mechanisms in Drug Relapse.	Werner CT et al.	—	2021	→
Epigenetic Regulation of Circadian Clocks and Its Involvement in Drug Addiction.	Saad L et al.	—	2021	→
Epigenetics of Drug Addiction.	Stewart AF et al.	—	2021	→
Hidden pharmacological activities of valproic acid: A new insight.	Singh D et al.	—	2021	→
Overexpressing Histone Deacetylase 5 in Rat Dorsal Striatum Alters Reward-Guided Decision-Making and Associated Neural Encoding.	Pribut HJ et al.	—	2021	→
The Gut Microbiome and Substance Use Disorder.	Russell JT et al.	—	2021	→
Early Life Stress- and Drug-Induced Histone Modifications Within the Ventral Tegmental Area.	Shepard RD et al.	—	2020	→
Neural substrates of habit.	Malvaez M	—	2020	→
Neurological correlates of brain reward circuitry linked to opioid use disorder (OUD): Do homo sapiens acquire or have a reward deficiency syndrome?	Gold MS et al.	—	2020	→
A glutamatergic insular-striatal projection regulates the reinstatement of cue-associated morphine-seeking behavior in mice.	Zhang R et al.	—	2019	→
A novel role for the actin-binding protein drebrin in regulating opiate addiction.	Martin JA et al.	—	2019	→
H3K4 dimethylation at FosB promoter in the striatum of chronic stressed rats promotes morphine-induced conditioned place preference.	Chen M et al.	—	2019	→
The Role of Epigenetics in Addiction: Clinical Overview and Recent Updates.	Beayno A et al.	—	2019	→
Novel role and regulation of HDAC4 in cocaine-related behaviors.	Penrod RD et al.	—	2018	→
Regulation of habit formation in the dorsal striatum.	Malvaez M et al.	—	2018	→
Dopamine D1 and D3 Receptors Modulate Heroin-Induced Cognitive Impairment through Opponent Actions in Mice.	Zhu Y et al.	—	2017	→
Emerging Role of Epigenetic Mechanisms in Alcohol Addiction.	Berkel TD et al.	—	2017	→
[Epigenetic mechanisms and alcohol use disorders: a potential therapeutic target].	Legastelois R et al.	—	2017	→
Epigenetics: a link between addiction and social environment.	Ajonijebu DC et al.	—	2017	→
NMDAR dependent intracellular responses associated with cocaine conditioned place preference behavior.	Nygard SK et al.	—	2017	→
Non-opioid anesthetic drug abuse among anesthesia care providers: a narrative review.	Zuleta-Alarcón A et al.	—	2017	→
A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction.	Bell RL et al.	—	2016	→
Epigenetic Modifications, Alcoholic Brain and Potential Drug Targets.	Jangra A et al.	—	2016	→
Mechanisms of HIV Transcriptional Regulation by Drugs of Abuse.	Tyagi M et al.	—	2016	→
Microinjection of histone deacetylase inhibitor into the ventrolateral orbital cortex potentiates morphine induced behavioral sensitization.	Wei L et al.	—	2016	→
The effects of cocaine on HIV transcription.	Tyagi M et al.	—	2016	→
The Nociceptin Receptor as an Emerging Molecular Target for Cocaine Addiction.	Lutfy K et al.	—	2016	→
Targeting glutamate uptake to treat alcohol use disorders.	Rao PS et al.	—	2015	→
Vitamin D receptor and epigenetics in HIV infection and drug abuse.	Chandel N et al.	—	2015	→
Curcumin alleviates neuropathic pain by inhibiting p300/CBP histone acetyltransferase activity-regulated expression of BDNF and cox-2 in a rat model.	Zhu X et al.	—	2014	→
D1/D5 receptors and histone deacetylation mediate the Gateway Effect of LTP in hippocampal dentate gyrus.	Huang YY et al.	—	2014	→
Early-life stress interactions with the epigenome: potential mechanisms driving vulnerability toward psychiatric illness.	Lewis CR et al.	—	2014	→
Epigenetic alterations in the brain associated with HIV-1 infection and methamphetamine dependence.	Desplats P et al.	—	2014	→
Histone-mediated epigenetics in addiction.	Hitchcock LN et al.	—	2014	→
Melatonin treatment induces interplay of apoptosis, autophagy, and senescence in human colorectal cancer cells.	Hong Y et al.	—	2014	→
Writers and readers of histone acetylation: structure, mechanism, and inhibition.	Marmorstein R et al.	—	2014	→
A DNA element regulates drug tolerance and withdrawal in Drosophila.	Li X et al.	—	2013	→
Effects of sodium butyrate on methamphetamine-sensitized locomotor activity.	Harkness JH et al.	—	2013	→
Epigenetic control of gene expression in the alcoholic brain.	Ponomarev I	—	2013	→
Epigenetic regulation of opioid-induced hyperalgesia, dependence, and tolerance in mice.	Liang DY et al.	—	2013	→
Epigenetics, drugs of abuse, and the retroviral promoter.	Shirazi J et al.	—	2013	→
Ethanol induces epigenetic modulation of prodynorphin and pronociceptin gene expression in the rat amygdala complex.	D'Addario C et al.	—	2013	→
Histone acetyltransferases: Rising ancient counterparts to protein kinases.	Yuan H et al.	—	2013	→
Hyposensitivity to gamma-aminobutyric acid in the ventral tegmental area during alcohol withdrawal: reversal by histone deacetylase inhibitors.	Arora DS et al.	—	2013	→
Imaging epigenetic regulation by histone deacetylases in the brain using PET/MRI with ¹⁸F-FAHA.	Yeh HH et al.	—	2013	→
Implications and limitations of cellular reprogramming for psychiatric drug development.	Tobe BT et al.	—	2013	→
Morphine withdrawal produces ERK-dependent and ERK-independent epigenetic marks in neurons of the nucleus accumbens and lateral septum.	Ciccarelli A et al.	—	2013	→
The role of histone acetylation in cocaine-induced neural plasticity and behavior.	Rogge GA et al.	—	2013	→
Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity.	Bell RL et al.	—	2012	→
Changes in histone acetylation in the prefrontal cortex of ethanol-exposed adolescent rats are associated with ethanol-induced place conditioning.	Pascual M et al.	—	2012	→
Current perspectives on the neurobiology of drug addiction: a focus on genetics and factors regulating gene expression.	Duncan JR	—	2012	→
Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood.	Davies MN et al.	—	2012	→
HDAC9 is implicated in schizophrenia and expressed specifically in post-mitotic neurons but not in adult neural stem cells.	Lang B et al.	—	2012	→
Methamphetamine causes differential alterations in gene expression and patterns of histone acetylation/hypoacetylation in the rat nucleus accumbens.	Martin TA et al.	—	2012	→
Alcohol exposure decreases CREB binding protein expression and histone acetylation in the developing cerebellum.	Guo W et al.	—	2011	→
A prospective on drug abuse-associated epigenetics and HIV-1 replication.	Pandhare J et al.	—	2011	→
CRACKing the histone code: cocaine's effects on chromatin structure and function.	LaPlant Q et al.	—	2011	→
Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder.	Dempster EL et al.	—	2011	→
Histone deacetylase inhibition decreases preference without affecting aversion for nicotine.	Pastor V et al.	—	2011	→
Repeated social defeat selectively increases δFosB expression and histone H3 acetylation in the infralimbic medial prefrontal cortex.	Hinwood M et al.	—	2011	→
Repeated toluene exposure modifies the acetylation pattern of histones H3 and H4 in the rat brain.	Sánchez-Serrano SL et al.	—	2011	→
Epigenetic gene silencing underlies C-fiber dysfunctions in neuropathic pain.	Uchida H et al.	—	2010	→
Genetic research: who is at risk for alcoholism.	Foroud T et al.	—	2010	→
HDAC9 links epigenetics to dendrite development (commentary on Sugo et al.).	Harkany T	—	2010	→
Synergistic interactions between histone deacetylase inhibitors and drugs of abuse.	Adachi M et al.	—	2009	→